Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy.

Developing potent medicinal alternates for tuberculosis (TB) is highly desirable due to the advent of drug-resistant lethal TB strains. Novel indole-isoniazid integrates have been synthesized with promising antimycobacterial action against the strain, and the nitro analogs and show the highest efficacy with a minimum inhibitory concentration of 1.25 μg/ml. The molecular docking studies against support the experimental findings. Indole conjugates display remarkable radical quenching efficiency, and compounds and demonstrate maximum IC values of 50.19 and 52.45 μg/ml, respectively. Pharmacokinetic analysis anticipated appreciable druggability for the title compounds. The notable bioaction of the indole-isoniazid templates projects them as potential lead in developing anti-TB medications with synergetic antioxidant action.