Asiwe Jerome Ndudi, Kolawole Tolunigba Abisola, Buduburisi Buduchim Rejoice, Adebayo Olusegun Gafar, Onuoha Ogechukwu Grace, Inegbenehi Saviour, Ademilusi Emmanuel Oluwaseun, Dapper Datonye Victor
Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Nigeria.
Department of Physiology, University of Ibadan, Ibadan, Nigeria.
Int J Environ Health Res. 2023 Dec;33(12):1331-1340. doi: 10.1080/09603123.2022.2086973. Epub 2022 Jun 10.
Lead is a hazardous naturally found heavy metal that has been reported to induce haematological alterations. Whether cabbage, a commonly consumed vegetable rich in antioxidants and anticancer compounds, can mitigate these alterations remains unknown. This study investigated the protective effect of cabbage juice against Lead-induced haematological changes. Twenty (20) male Wistar rats were randomly selected into four groups (n = 5) and given distilled water (1 ml/100 g ), Lead acetate (25 mg/kg ), Cabbage juice (1 ml/100 g ), and Lead acetate with Cabbage juice. All treatments were given orally for 28 days. Lead exposure induces normocytic normochromic anemia with substantial leukocytosis, lymphocytopenia, and hyperfibrinogenemia. Lead-intoxicated animals had significantly higher haemolysis and prolonged clotting times. However, cabbage juice reverses these adverse haematological and haemorheological changes induced by Lead acetate. Conclusively, cabbage juice demonstrated antioxidant, anti-inflammatory, anti-thrombotic, and immunomodulatory properties, as well as the ability to protect the red blood cell membrane from damage caused by Lead-induced osmotic stress.
铅是一种天然存在的有害重金属，据报道会引起血液学改变。富含抗氧化剂和抗癌化合物的常见食用蔬菜卷心菜是否能减轻这些改变尚不清楚。本研究调查了卷心菜汁对铅诱导的血液学变化的保护作用。将20只雄性Wistar大鼠随机分为四组（n = 5），分别给予蒸馏水（1毫升/100克）、醋酸铅（25毫克/千克）、卷心菜汁（1毫升/100克）以及醋酸铅与卷心菜汁的组合。所有处理均经口给予28天。铅暴露会导致正细胞正色素性贫血，并伴有显著的白细胞增多、淋巴细胞减少和高纤维蛋白原血症。铅中毒的动物溶血明显增加，凝血时间延长。然而，卷心菜汁可逆转醋酸铅诱导的这些不良血液学和血液流变学变化。总之，卷心菜汁具有抗氧化、抗炎、抗血栓形成和免疫调节特性，以及保护红细胞膜免受铅诱导的渗透压应激损伤的能力。
