Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Am J Chin Med. 2014;42(1):189-206. doi: 10.1142/S0192415X1450013X.
The widely used culinary vegetable, red cabbage (Brassica oleracea L. Var. capitata f. rubra), of the Brassicaceae family contains biologically potent anthocyanins and a myriad of antioxidants. Previous studies have shown that the pharmacological effects of red cabbage in vivo are redox-sensitive. The present study explored whether red cabbage modulates various histopathological and biochemical parameters in rats administered with a cholesterol-rich diet (CRD). To this end, prolonged administration of a lyophilized-aqueous extract of red cabbage (250 and 500 mg/kg body weight) significantly blunted the imbalances in lipids, liver enzymes and renal osmolytes induced by the CRD. The effects of red cabbage were compared to simvastatin (30 mg/kg body weight) treated rats. Estimation of malondialdehyde and non-protein sulfhydryls revealed robust antioxidant properties of red cabbage. Histopathological analysis of livers from rats administered with red cabbage showed marked inhibition in inflammatory and necrotic changes triggered by CRD. Similarly, in vitro studies using a 2',7'-Dichlorofluorescein-based assay showed that red cabbage conferred cytoprotective effects in cultured HepG2 cells. In conclusion, the present study discloses the potential therapeutic effects of red cabbage in dyslipidemia as well as hepatic injury, that is at least, partly mediated by its antioxidant properties.
广泛食用的蔬菜，红甘蓝（ Brassica oleracea L. Var. capitata f. rubra ），属于十字花科，含有生物活性很强的花青素和无数的抗氧化剂。先前的研究表明，红甘蓝在体内的药理作用是氧化还原敏感的。本研究探讨了富含胆固醇的饮食（CRD）是否会调节红甘蓝在大鼠体内的各种组织病理学和生化参数。为此，长期给予红甘蓝冻干水提物（250 和 500mg/kg 体重）可显著减轻 CRD 引起的脂质、肝酶和肾渗透溶质的失衡。将红甘蓝的作用与辛伐他汀（30mg/kg 体重）处理的大鼠进行了比较。丙二醛和非蛋白巯基的估算显示了红甘蓝具有很强的抗氧化特性。给予红甘蓝的大鼠肝脏的组织病理学分析显示，CRD 引发的炎症和坏死变化明显受到抑制。同样，使用 2'，7'-二氯荧光素基测定法进行的体外研究表明，红甘蓝在培养的 HepG2 细胞中具有细胞保护作用。总之，本研究揭示了红甘蓝在血脂异常和肝损伤中的潜在治疗作用，至少部分是通过其抗氧化特性介导的。
