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关于非哺乳动物有颌脊椎动物在 MHC 分子的抗原加工和肽加载方面给我们的启示。

Some thoughts about what non-mammalian jawed vertebrates are telling us about antigen processing and peptide loading of MHC molecules.

机构信息

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK; Institute for Immunology and Infection Research, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK.

出版信息

Curr Opin Immunol. 2022 Aug;77:102218. doi: 10.1016/j.coi.2022.102218. Epub 2022 Jun 7.

DOI:10.1016/j.coi.2022.102218
PMID:35687979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9586880/
Abstract

The major histocompatibility complex (MHC) of mammals encodes highly polymorphic classical class I and class II molecules with crucial roles in immune responses, as well as various nonclassical molecules encoded by the MHC and elsewhere in the genome that have a variety of functions. These MHC molecules are supported by antigen processing and peptide loading pathways which are well-understood in mammals. This review considers what has been learned about the MHC, MHC molecules and the supporting pathways in non-mammalian jawed vertebrates. From the initial understanding from work with the chicken MHC, a great deal of diversity in the structure and function has been found. Are there underlying principles?

摘要

哺乳动物的主要组织相容性复合体 (MHC) 编码高度多态性的经典 I 类和 II 类分子，这些分子在免疫反应中起着至关重要的作用，此外还有各种由 MHC 和基因组其他部位编码的非经典分子，具有多种功能。这些 MHC 分子由抗原加工和肽加载途径支持，这些途径在哺乳动物中得到了很好的理解。本综述考虑了在无颌脊椎动物中 MHC、MHC 分子和支持途径方面的研究进展。从最初对鸡 MHC 的研究中，发现了结构和功能的多样性。是否存在潜在的原则？

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/d99b2dd78bd2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/98101ee3e6c7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/34706be5b0fb/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/60f6ede8be3a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/d99b2dd78bd2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/98101ee3e6c7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/34706be5b0fb/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/60f6ede8be3a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e3f/9586880/d99b2dd78bd2/gr4.jpg

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The new W family reconstructs the evolution of MHC genes.新的W家族重构了MHC基因的进化历程。
Proc Natl Acad Sci U S A. 2022 Feb 1;119(5). doi: 10.1073/pnas.2122079119.
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Spotlight on TAP and its vital role in antigen presentation and cross-presentation.聚焦 TAP 及其在抗原呈递和交叉呈递中的重要作用。
Immunogenetics. 2023 Dec;75(6):479-493. doi: 10.1007/s00251-023-01319-3. Epub 2023 Sep 22.
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Mol Immunol. 2022 Feb;142:105-119. doi: 10.1016/j.molimm.2021.12.013. Epub 2021 Dec 29.
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Discovery of an ancient MHC category with both class I and class II features.发现具有 I 类和 II 类特征的古老 MHC 类别。
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