Fraschini F, Scaglione F, Scarpazza G, Marchi M, Braga P C
Chemotherapy. 1987;33(2):85-92. doi: 10.1159/000238479.
Sagamicin is an aminoglycosidic antibiotic produced by Micromonospora sagamiensis, chemically related with gentamicin. Single- and multiple-dose pharmacokinetics have been investigated in patients affected by bronchopulmonary infections treated with 60 mg sagamicin i.m. every 12 h. The two concentration-time curves for sputum and serum are parallel; while there is no evidence of accumulation in the serum at the 7th day of treatment, sagamicin concentrations in the sputum are significantly higher on the 7th day, and this is also confirmed by a remarkable difference between the two AUC values. The good penetration power of sagamicin into sputum makes this antibiotic useful for the treatment of infections of the respiratory tract.
相模霉素是由相模小单孢菌产生的一种氨基糖苷类抗生素，与庆大霉素有化学相关性。已对每12小时肌肉注射60mg相模霉素治疗支气管肺部感染的患者进行了单剂量和多剂量药代动力学研究。痰液和血清的两条浓度-时间曲线是平行的；虽然在治疗第7天时血清中没有蓄积的证据，但痰液中的相模霉素浓度在第7天时显著更高，并且两个AUC值之间的显著差异也证实了这一点。相模霉素对痰液的良好渗透能力使得这种抗生素可用于治疗呼吸道感染。
