Fraschini F, Braga P C, Scaglione F, Zanollo A, Politi P, Odero R, Trazzi R
Int J Clin Pharmacol Res. 1987;7(1):51-8.
In order to assess the therapeutic activity of an antibiotic, not only its serum kinetics but also its kinetics in the peripheral tissues must be determined, thus evaluating the specific power of penetration of the drug. Sagamicin is an aminoglycosidic basic antibiotic closely related to gentamicin and its penetration rate into lungs, kidney and prostate, together with its serum concentrations time-course, were investigated. The findings obtained showed that this antibiotic attained a good distribution in the peripheral tissues, where it easily reached therapeutic levels.
为了评估一种抗生素的治疗活性，不仅必须测定其血清动力学，还必须测定其在外周组织中的动力学，从而评估药物的特定渗透能力。紫苏霉素是一种与庆大霉素密切相关的氨基糖苷类碱性抗生素，研究了其在肺、肾和前列腺中的渗透速率及其血清浓度随时间的变化过程。所获得的结果表明，这种抗生素在外周组织中分布良好，很容易达到治疗水平。
