Center for Evaluation and Surveys Research, National Institute of Public Health, Av. Universidad #655. Colonia Santa María Ahuacatitlan, Cuernavaca, Morelos ZC 62100, Mexico.
Gerontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse). CERPOP, Université de Toulouse, Inserm, UPS, Toulouse, France.
Maturitas. 2022 Jul;161:49-54. doi: 10.1016/j.maturitas.2022.02.005. Epub 2022 Feb 26.
Intrinsic capacity (IC) is a key concept within the World Health Organization's (WHO) healthy aging model. The systematic assessment of IC could provide a better understanding of the functional trajectories of individuals. Our aims were to identify the longitudinal trajectories of IC and estimate their association with quality of life and disability.
The study data comes from the three waves of the WHO Study on global AGEing and adult health (SAGE) in Mexico (2009, 2014, 2017). In total, 2735 adults aged 50 years or more were included. An IC score was constructed using item response theory. We used growth mixture modeling (GMM) to investigate the longitudinal trajectories of IC. Three-level linear mixed effect models were used to estimate the associations of IC with quality of life and disability.
Disability was measured using the WHO Disability Assessment Schedule (WHODAS 2.0) and quality of life using the WHOQOL (WHO Quality of Life) instrument.
Three classes were identified: low baseline IC with a steeply decreasing trajectory, medium baseline IC with a slightly decreasing trajectory, and high baseline IC with a moderately increasing trajectory. The class with the better trajectory (higher baseline IC score and a moderately increasing pattern) exhibited higher quality-of-life scores and lower disability scores.
The findings show that older Mexican adults exhibit different IC trajectories, and that these may be associated with quality of life and disability. Results highlight the need for health policies and strategies to maintain intrinsic capacity and to promote primary prevention.
内在能力（IC）是世界卫生组织（WHO）健康老龄化模型中的一个关键概念。对 IC 的系统评估可以更好地了解个体的功能轨迹。我们的目的是确定 IC 的纵向轨迹，并估计其与生活质量和残疾的关联。
本研究的数据来自墨西哥的 WHO 全球老龄化和成人健康研究（SAGE）的三个波次（2009 年、2014 年和 2017 年）。共有 2735 名 50 岁及以上的成年人被纳入研究。使用项目反应理论构建 IC 评分。我们使用增长混合建模（GMM）来研究 IC 的纵向轨迹。使用三级线性混合效应模型来估计 IC 与生活质量和残疾的关联。
使用世界卫生组织残疾评估量表（WHODAS 2.0）测量残疾，使用世界卫生组织生活质量（WHOQOL）工具测量生活质量。
确定了三个类别：基线 IC 较低且轨迹急剧下降、基线 IC 中等且轨迹略有下降、基线 IC 较高且轨迹中度增加。轨迹较好的类别（较高的基线 IC 评分和中度增加模式）表现出较高的生活质量评分和较低的残疾评分。
研究结果表明，年龄较大的墨西哥成年人表现出不同的 IC 轨迹，这些轨迹可能与生活质量和残疾有关。结果强调需要制定卫生政策和战略来维持内在能力并促进初级预防。
