Wang Youting, Tang Nan, Shao Mengqi, Song Jie, Su Qingqing, Gao Yuan
Chinese People's Liberation Army (PLA) Medical School, Beijing, 100853, China.
Department of Nursing, First Medical Center, PLA General Hospital, Haidian District, Fuxing Road No.28, Beijing, 100853, China.
BMC Geriatr. 2025 Jun 4;25(1):407. doi: 10.1186/s12877-025-05938-1.
Intrinsic Capacity (IC) is a crucial measure of the comprehensive physiological and psychological capabilities of older adults, playing a key role in assessing healthy aging. This systematic review aims to explore the trajectories of IC in older adults, as well as the associated determinants and health outcomes. By searching through PubMed, Embase, Ovid, and Web of Science databases, we identified 13 studies that met our inclusion criteria. To ensure the rigor of the review, the Newcastle-Ottawa Scale (NOS) critical appraisal tool for cohort studies and the Guidelines for Reporting on Latent Trajectory Studies were employed to assess the quality of the studies included. When IC is represented as a single composite value, there are primarily three trajectory types: declining trajectory (characterized by a sharp, moderate, or mild decline from baseline IC), stable trajectory (little change compared to baseline IC), and high trajectory (high baseline IC with an increasing trend). When IC is broken down into individual dimensions, these trajectories primarily reflect the degree of impairment in different domains and changes in IC status. The trajectories can be divided into robust status (no impaired domains, stable IC status), mild impairment (impairment in 1-2 domains, mild IC impairment), and severe impairment (impairment in multiple domains, severe IC impairment). Factors influencing IC trajectories include age, gender, education level, ethnicity, number of chronic diseases, marital status, perceived financial adequacy, economic assistance status, self-assessed health status, and inflammatory biomarkers (such as IL-6, TNFR-1, and GDF-15). Adverse IC trajectory patterns are associated with increased mortality, quality of life, disability, frailty, and fall risk. Future research should focus on changes in IC at the end of life, increase the number of assessment time points, use objective measurement methods, and consider experimental designs to better understand the mechanisms behind IC trajectories, providing a scientific basis for targeted interventions.
内在能力（IC）是衡量老年人综合生理和心理能力的关键指标，在评估健康老龄化方面发挥着关键作用。本系统综述旨在探讨老年人IC的轨迹，以及相关的决定因素和健康结果。通过检索PubMed、Embase、Ovid和Web of Science数据库，我们确定了13项符合纳入标准的研究。为确保综述的严谨性，采用队列研究的纽卡斯尔-渥太华量表（NOS）批判性评估工具和潜在轨迹研究报告指南来评估纳入研究的质量。当IC表示为单一综合值时，主要有三种轨迹类型：下降轨迹（其特征是从基线IC急剧、中度或轻度下降）、稳定轨迹（与基线IC相比变化很小）和高轨迹（基线IC高且呈上升趋势）。当IC分解为各个维度时，这些轨迹主要反映不同领域的受损程度和IC状态的变化。轨迹可分为强健状态（无受损领域，IC状态稳定）、轻度受损（1 - 2个领域受损，IC轻度受损）和重度受损（多个领域受损，IC重度受损）。影响IC轨迹的因素包括年龄、性别、教育水平、种族、慢性病数量、婚姻状况、感知财务充足程度、经济援助状况、自我评估健康状况和炎症生物标志物（如IL - 6、TNFR - 1和GDF - 15）。不良的IC轨迹模式与死亡率增加、生活质量、残疾、虚弱和跌倒风险相关。未来的研究应关注生命末期IC的变化，增加评估时间点的数量，使用客观测量方法，并考虑实验设计，以更好地理解IC轨迹背后的机制，为有针对性的干预提供科学依据。
Cochrane Database Syst Rev. 2022-2-1
Ageing Res Rev. 2024-3
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