Servicio de Hepatología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, España.
Servicio de Hepatología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, España.
Med Clin (Barc). 2022 Sep 23;159(6):289-298. doi: 10.1016/j.medcli.2022.04.004. Epub 2022 Jun 7.
Autoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly unknown and commonly affects women of all ages. It is characterized by increase in transaminase and immunoglobulin G levels, autoantibodies, and portal inflammatory infiltrate with interface hepatitis in the liver biopsy. The treatment is based on the combination of corticoids and azathioprine, but 20-40% of patients require second- or third-line therapies due to intolerance or insufficient response. Here, we will revise the most important aspects regarding the diagnosis and treatment of autoimmune hepatitis emphasizing the challenges faced in clinical practice.
自身免疫性肝炎是一种慢性肝脏炎症性疾病。病因部分未知，常见于各年龄段女性。其特征是肝活检时转氨酶和免疫球蛋白 G 水平升高、出现自身抗体、门脉炎症浸润伴界面肝炎。治疗基于皮质激素和硫唑嘌呤的联合应用，但由于不耐受或反应不足，20-40%的患者需要二线或三线治疗。在此，我们将重点介绍临床实践中面临的挑战，修订自身免疫性肝炎诊断和治疗的最重要方面。
