Türközer Halide Bilge, Lizano Paulo, Adhan Iniya, Ivleva Elena I, Lutz Olivia, Zeng Victor, Zeng Alexandria, Raymond Nicholas, Bannai Deepthi, Lee Adam, Bishop Jeffrey R, Clementz Brett A, Pearlson Godfrey D, Sweeney John A, Gershon Elliot S, Keshavan Matcheri S, Tamminga Carol A
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas; Division of Child and Adolescent Psychiatry, Massachusetts General Hospital and McLean Hospital, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Biol Psychiatry. 2022 Sep 1;92(5):396-406. doi: 10.1016/j.biopsych.2022.03.023. Epub 2022 Apr 12.
Impairments of the visual system are implicated in psychotic disorders. However, studies exploring visual cortex (VC) morphology in this population are limited. Using data from the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium, we examined VC structure in psychosis probands and their first-degree relatives (RELs), sex differences in VC measures, and their relationships with cognitive and peripheral inflammatory markers.
Cortical thickness, surface area, and volume of the primary (Brodmann area 17/V1) and secondary (Brodmann area 18/V2) visual areas and the middle temporal (V5/MT) region were quantified using FreeSurfer version 6.0 in psychosis probands (n = 530), first-degree RELs (n = 544), and healthy control subjects (n = 323). Familiality estimates were determined for probands and RELs. General cognition, response inhibition, and emotion recognition functions were assessed. Systemic inflammation was measured in a subset of participants.
Psychosis probands demonstrated significant area, thickness, and volume reductions in V1, V2, and MT, and their first-degree RELs demonstrated area and volume reductions in MT compared with control subjects. There was a higher degree of familiality for VC area than thickness. Area and volume reductions in V1 and V2 were sex dependent, affecting only female probands in a regionally specific manner. Reductions in some VC regions were correlated with poor general cognition, worse response inhibition, and increased C-reactive protein levels.
The visual cortex is a site of significant pathology in psychotic disorders, with distinct patterns of area and thickness changes, sex-specific and regional effects, potential contributions to cognitive impairments, and association with C-reactive protein levels.
视觉系统损伤与精神障碍有关。然而，探索该人群视觉皮层（VC）形态的研究有限。利用双相情感障碍-精神分裂症中间表型网络联盟的数据，我们研究了精神病先证者及其一级亲属（RELs）的VC结构、VC测量中的性别差异，以及它们与认知和外周炎症标志物的关系。
使用FreeSurfer 6.0版本对精神病先证者（n = 530）、一级亲属（n = 544）和健康对照者（n = 323）的初级视觉区（布罗德曼区17/V1）、次级视觉区（布罗德曼区18/V2）和颞中区（V5/MT）的皮质厚度、表面积和体积进行量化。确定了先证者和亲属的家族聚集性估计值。评估了一般认知、反应抑制和情绪识别功能。在一部分参与者中测量了全身炎症。
与对照者相比，精神病先证者的V1、V2和MT区的面积、厚度和体积显著减小，其一级亲属的MT区面积和体积减小。VC面积的家族聚集性程度高于厚度。V1和V2区的面积和体积减小具有性别依赖性，仅以区域特异性方式影响女性先证者。一些VC区域的减小与一般认知能力差、反应抑制能力差和C反应蛋白水平升高相关。
视觉皮层是精神障碍中重要的病理部位，具有面积和厚度变化的独特模式、性别特异性和区域效应、对认知障碍的潜在影响以及与C反应蛋白水平的关联。
