视网膜电生理改变与早期精神病性病程中的认知有关。
Retinal electrophysiological alterations are associated with cognition in early course psychosis.
作者信息
Molho Willa, Stiltner Brendan, Raymond Nicolas, Kiely Chelsea, Trotti Rebekah, Harris Caroline, Bannai Deepthi, Keshavan Matcheri, Silverstein Steven, Lizano Paulo
机构信息
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
出版信息
Schizophr Res. 2024 Dec;274:137-141. doi: 10.1016/j.schres.2024.09.013. Epub 2024 Sep 17.
Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial Spearman correlations were performed between fERG and BAC. Lower Photopic-1b and Scotopic-3b amplitudes were identified in ECP vs. HCs. Correlations were significant (p<0.05) between BAC Composite score and a-wave S3a and S2a and b-wave S2b and S3b conditions. Thus, ECP was characterized by lower ERG responses, and lower rod/cone/bipolar cell responses were related to poorer cognition.
视网膜电生理改变与精神病有关，但在早期精神病（ECP）中它们与认知的关系研究不足。对24名对照者（HC）和27名ECP个体进行了简易认知评估（BAC）和闪光视网膜电图（fERG）检查。对fERG和BAC进行了偏斯皮尔曼相关性分析。与HC相比，ECP个体的明视-1b和暗视-3b振幅较低。BAC综合评分与a波S3a和S2a以及b波S2b和S3b条件之间的相关性显著（p<0.05）。因此，ECP的特征是ERG反应较低，而较低的视杆/视锥/双极细胞反应与较差的认知有关。
Zotero 插件