Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, Shijiazhuang 050017, China.
Undergraduate of College of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
Ecotoxicol Environ Saf. 2022 Aug;241:113735. doi: 10.1016/j.ecoenv.2022.113735. Epub 2022 Jun 8.
Evidence on the health benefits of vitamin C supplementation in highly polluted areas has not been evaluated. We aimed to evaluate whether dietary vitamin C supplementation can improve vascular health linked to particulate matter (PM) exposure. A randomised double-blind crossover trial involving 58 health young adults was performed in Shijiazhuang, China in 2018. All subjects were randomly assigned to the vitamin C supplementation group (2000 mg/d) or placebo group for a week alternating with a 2 week washout period. Fifteen circulating biomarkers were measured. Linear mixed-effect model was applied to evaluate the effect of vitamin C supplementation on health outcomes. The average concentrations of PM and PM were 164.91 and 327.05 μg/m, respectively. Vitamin C supplementation was significantly associated with a 19.47% decrease in interleukin-6 (IL-6), 17.30% decrease in tumour necrosis factor-a (TNF-α), 34.01% decrease in C-reactive protein (CRP), 3.37% decrease in systolic blood pressure (SBP) and 6.03% decrease in pulse pressure (PP). Furthermore, glutathione peroxidase (GSH-Px) was significantly increased by 7.15%. Sex-subgroup analysis showed that vitamin C significantly reduced TNF-α by 27.85% in male participants and significantly increased APOB by 6.28% and GSH-Px by 14.47% only in female participants. This study indicated that vitamin C supplementation may protect vascular vessels against PM exposure among healthy young adults in China.
关于维生素 C 补充剂在高污染地区对健康益处的证据尚未得到评估。我们旨在评估膳食维生素 C 补充剂是否可以改善与颗粒物（PM）暴露相关的血管健康。2018 年，在中国石家庄进行了一项涉及 58 名健康年轻成年人的随机双盲交叉试验。所有受试者均随机分为维生素 C 补充组（2000mg/d）或安慰剂组，每周交替服用一周，然后进行 2 周洗脱期。测量了 15 种循环生物标志物。应用线性混合效应模型评估维生素 C 补充对健康结果的影响。PM 和 PM 的平均浓度分别为 164.91 和 327.05μg/m。维生素 C 补充与白细胞介素-6（IL-6）降低 19.47%、肿瘤坏死因子-α（TNF-α）降低 17.30%、C 反应蛋白（CRP）降低 34.01%、收缩压（SBP）降低 3.37%和脉压（PP）降低 6.03%显著相关。此外，谷胱甘肽过氧化物酶（GSH-Px）显著增加了 7.15%。性别亚组分析表明，维生素 C 可使男性参与者的 TNF-α显著降低 27.85%，仅使女性参与者的 APOB 显著增加 6.28%和 GSH-Px 增加 14.47%。这项研究表明，维生素 C 补充剂可能在中国健康年轻成年人中保护血管免受 PM 暴露的影响。
