Department of Paediatric Haematology and Oncology, University Hospital Bonn, Bonn, Germany.
Department of Paediatric Haematology and Oncology, University Hospital Bonn, Bonn, Germany.
Eur J Cancer. 2022 Jul;170:209-235. doi: 10.1016/j.ejca.2022.03.018. Epub 2022 Jun 8.
The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures.
To this end, we linked physical functioning scores from the Paediatric Quality of Life Inventory (PedsQL) and the Paediatric Quality of Life Questionnaire (PEDQOL) to the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) for adults. Samples from the EURAMOS-1 QoL sub-study of 75 (PedsQL) and 112 (PEDQOL) adolescent osteosarcoma patients were concurrently administered both paediatric and adult questionnaires on 98 (PedsQL) and 156 (PEDQOL) occasions. We identified corresponding scores using the single-group equipercentile linking method.
Linked physical functioning scores showed sufficient concordance to the EORTC QLQ-C30: Lin's ρ = 0.74 (PedsQL) and Lin's ρ = 0.64 (PEDQOL).
Score linking provides clinicians and researchers with a common metric for assessing QoL with PRO measures across the entire lifespan of patients.
现有的生活质量（QoL）评估问卷是针对特定年龄组的，这限制了可比性并阻碍了纵向分析。然而，测量的可比性是获得科学证据的必要条件。为了解决这个问题，我们评估了协调儿科和成人患者报告结局（PRO）测量数据的可行性。
为此，我们将儿科生活质量量表（PedsQL）和儿科生活质量问卷（PEDQOL）的身体功能评分与成人欧洲癌症研究与治疗组织核心问卷（EORTC QLQ-C30）相联系。同时对来自 EURAMOS-1 QoL 子研究的 75 名（PedsQL）和 112 名（PEDQOL）青少年骨肉瘤患者进行了样本调查，这些患者在 98 次（PedsQL）和 156 次（PEDQOL）中同时使用了这两种儿科和成人问卷。我们使用单组等百分位链接方法确定了相应的分数。
链接后的身体功能评分与 EORTC QLQ-C30 具有足够的一致性：Lin's ρ=0.74（PedsQL）和 Lin's ρ=0.64（PEDQOL）。
评分链接为临床医生和研究人员提供了一种使用 PRO 测量评估整个患者生命周期生活质量的通用指标。
