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Reading oscillatory instructions: How cells achieve time-dependent responses to oscillating transcription factors.

作者信息

Venkatachalam Veena, Jambhekar Ashwini, Lahav Galit

机构信息

Department of Systems Biology, Blavatnik Institute at Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA; Department of Radiation Oncology, Dana-Farber Brigham Cancer Center, 75 Francis St, Boston, MA 02115, USA.

Department of Systems Biology, Blavatnik Institute at Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA; Ludwig Center at Harvard, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215, USA.

出版信息

Curr Opin Cell Biol. 2022 Aug;77:102099. doi: 10.1016/j.ceb.2022.102099. Epub 2022 Jun 9.

DOI:10.1016/j.ceb.2022.102099
PMID:35690043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9533215/
Abstract
摘要

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Cell Rep. 2021 Nov 9;37(6):109967. doi: 10.1016/j.celrep.2021.109967.
2
NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages.NF-κB 动力学决定了巨噬细胞中表观基因组重编程的刺激特异性。
Science. 2021 Jun 18;372(6548):1349-1353. doi: 10.1126/science.abc0269.
3
Genome-wide off-rates reveal how DNA binding dynamics shape transcription factor function.全基因组解离速率揭示了 DNA 结合动力学如何塑造转录因子的功能。
Mol Syst Biol. 2020 Oct;16(10):e9885. doi: 10.15252/msb.20209885.
4
Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics.光遗传学控制揭示了转录因子核易位动力学的不同启动子解释。
Cell Syst. 2020 Oct 21;11(4):336-353.e24. doi: 10.1016/j.cels.2020.08.009. Epub 2020 Sep 7.
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Long-term association of a transcription factor with its chromatin binding site can stabilize gene expression and cell fate commitment.转录因子与其染色质结合位点的长期关联可以稳定基因表达和细胞命运决定。
Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15075-15084. doi: 10.1073/pnas.2000467117. Epub 2020 Jun 12.
6
Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism.核肌球蛋白 1 通过基于染色质的机制响应 DNA 损伤激活 p21 基因转录。
Commun Biol. 2020 Mar 11;3(1):115. doi: 10.1038/s42003-020-0836-1.
7
Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression.基因调控策略可解码 NFκB 动力学的持续时间,有助于 LPS 与 TNF 特异性基因表达。
Cell Syst. 2020 Feb 26;10(2):169-182.e5. doi: 10.1016/j.cels.2019.12.004. Epub 2020 Jan 22.
8
p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions.p53 脉冲调制通过调节靶基因启动子来调节细胞命运决定。
Mol Syst Biol. 2019 Sep;15(9):e8685. doi: 10.15252/msb.20188685.
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Live-cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting.活细胞成像揭示了转录因子、核小体和爆发之间的相互作用。
EMBO J. 2019 Jun 17;38(12). doi: 10.15252/embj.2018100809. Epub 2019 May 17.
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Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription.三维基因组中的昼夜节律:染色质相互作用对周期性转录的影响。
Clin Epigenetics. 2019 May 15;11(1):79. doi: 10.1186/s13148-019-0677-2.