FOM Institute AMOLF, Science Park 104, 1098XE Amsterdam, The Netherlands.
Phys Rev Lett. 2012 Mar 9;108(10):108104. doi: 10.1103/PhysRevLett.108.108104. Epub 2012 Mar 8.
In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude-encoding scheme of constant signals remain unclear. Here we study the dynamics of a simple model gene promoter in response to oscillating and constant transcription factor signals. We find that in biologically relevant parameter regimes an oscillating input can produce a more constant protein level than a constant input. Our results suggest that oscillating signals may be used to minimize noise in gene regulation.
在生化信号中，信息通常被编码为振荡信号。然而，与恒定信号的幅度编码方案相比，这种编码策略的优势尚不清楚。在这里，我们研究了简单模型基因启动子对振荡和恒定转录因子信号的反应动力学。我们发现，在生物学相关的参数范围内，振荡输入可以产生比恒定输入更稳定的蛋白质水平。我们的结果表明，振荡信号可用于最小化基因调控中的噪声。
