Kampalath B N, Liau M C, Burzynski B, Burzynski S R
Drugs Exp Clin Res. 1987;13 Suppl 1:51-5.
The effect of Antineoplaston A10 (AA10), an amino acid derivative isolated from human urine, has been studied on pulmonary adenoma formation resulting from intragastric administration of benzo(a)pyrene(BP) to A/HeJ mice. Two doses of BP, 3 mg each, administered two weeks apart, induced an average of 6.86 tumours within 157 days in the control animals (Tumorigenic Index 437). One per cent of AA10 (w/w) given in mouse food for one week prior to, and then continued after the administration of BP, produced a 70% reduction in the total number of tumours in the test groups.
从人尿中分离出的氨基酸衍生物抗瘤氨酸A10（AA10），对给A/HeJ小鼠胃内注射苯并(a)芘（BP）所致肺腺瘤形成的影响进行了研究。间隔两周给予两次剂量均为3 mg的BP，在157天内，对照动物平均诱发6.86个肿瘤（致瘤指数437）。在给予BP之前一周，然后在给予BP之后继续在小鼠食物中添加1%（w/w）的AA10，试验组肿瘤总数减少了70%。
