Hashimoto K, Koga T, Shintomi Y, Tanaka M, Kakegawa T, Tsuda H, Hara H
1st Department of Surgery, Kurume University School of Medicine.
Nihon Gan Chiryo Gakkai Shi. 1990 Jan 20;25(1):1-5.
We report the effects of Antineoplaston A-10 Injection on the growth curve of human breast cancer (R-27) serially transplanted to athymic mice. The intraperitoneal administration of 1/4 LD-50 (50 mg/mouse) of Antineoplaston A-10 Injection every day and 1/2 LD-50 (100 mg/mouse) every other day for 35 days was found to significantly inhibit the growth curve and also the 3H-TdR uptake was inhibited by 73.7% in those given 1/4 LD-50 and by 77.1% in those given 1/2 LD-50. The tumor histology in both groups showed necrosis but no lymphocyte infiltration.
我们报告了抗瘤酮A - 10注射液对连续移植到无胸腺小鼠体内的人乳腺癌（R - 27）生长曲线的影响。结果发现，每天腹腔注射1/4半数致死剂量（LD - 50，50毫克/只小鼠）的抗瘤酮A - 10注射液，隔天注射1/2 LD - 50（100毫克/只小鼠），持续35天，可显著抑制生长曲线，并且在给予1/4 LD - 50剂量的小鼠中，3H - TdR摄取被抑制了73.7%，在给予1/2 LD - 50剂量的小鼠中，3H - TdR摄取被抑制了77.1%。两组的肿瘤组织学检查均显示有坏死，但无淋巴细胞浸润。
