Department of Translational Medicine, School of Medical Sciences, State University of Campinas, Campinas, Brazil.
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Mol Cell Endocrinol. 2022 Aug 1;553:111697. doi: 10.1016/j.mce.2022.111697. Epub 2022 Jun 8.
Maternal energy metabolism undergoes a singular adaptation during lactation that allows for the caloric enrichment of milk. Changes in the mammary gland, changes in the white adipose tissue, brown adipose tissue, liver, skeletal muscles and endocrine pancreas are pivotal for this adaptation. The present review details the landmark studies describing the enzymatic modulation and the endocrine signals behind these metabolic changes. We will also update this perspective with data from recent studies showing transcriptional and post-transcriptional mechanisms that mediate the adaptation of the maternal metabolism to lactation. The present text will also bring experimental and observational data that describe the long-term consequences that short periods of lactation impose to maternal metabolism.
哺乳期母体的能量代谢会发生特殊适应性变化，从而使乳汁中的热量更为丰富。乳腺、白色脂肪组织、棕色脂肪组织、肝脏、骨骼肌和内分泌胰腺的变化对于这种适应性改变至关重要。本综述详细描述了描述这些代谢变化背后的酶调节和内分泌信号的里程碑式研究。我们还将用最近的研究数据更新这一观点，这些数据表明了介导母体代谢适应哺乳期的转录和转录后机制。本文还将提供描述短期哺乳期对母体代谢产生的长期影响的实验和观察数据。
