Bailey R T, Bonavina L, McChesney L, Spires K J, Muilenburg M I, McGill J E, DeMeester T R
Drug Intell Clin Pharm. 1987 Mar;21(3):282-5. doi: 10.1177/106002808702100311.
The tendency of a gelatin capsule to lodge in the esophagus, dissolve, and release its contents, as a potential etiology of drug-induced esophageal injury, was studied in 18 asymptomatic volunteers. Their ages ranged from 21 to 81 years, with nine subjects over 70 years old. Esophageal transit time of liquids was measured in all subjects after which the esophageal transit time of a #00 gelatin capsule containing technetium (99mTc) sulfur colloid was measured with a 120 ml and a 15 ml water bolus. The capsule lodged in three subjects (17 percent) with the 120 ml bolus and in 11 subjects (61 percent) with the 15 ml bolus. Esophageal manometry demonstrated a lower mean amplitude of esophageal contractions in subjects in whom the capsule lodged with the 120 ml bolus and in the elderly subjects. We conclude that the esophageal transit time of a gelatin capsule is related to the volume of fluid chaser. Our findings that a lower amplitude of esophageal contractions was associated with elderly patients and those in whom the capsule lodged with the large fluid bolus are worthy of further investigation.
在18名无症状志愿者中研究了明胶胶囊滞留在食管、溶解并释放其内容物作为药物性食管损伤潜在病因的倾向。他们的年龄在21岁至81岁之间，其中9名受试者年龄超过70岁。测量了所有受试者液体的食管通过时间，之后用120毫升和15毫升水团测量含锝（99mTc）硫化胶体的#00明胶胶囊的食管通过时间。胶囊在使用120毫升水团时滞留在3名受试者（17%）中，在使用15毫升水团时滞留在11名受试者（61%）中。食管测压显示，在胶囊随120毫升水团滞留的受试者和老年受试者中，食管收缩的平均幅度较低。我们得出结论，明胶胶囊的食管通过时间与液体冲量的体积有关。我们的研究结果表明，食管收缩幅度较低与老年患者以及胶囊随大量液体团滞留的患者有关，值得进一步研究。
