Instituto Adolfo Lutz, Avenida Dr. Arnaldo, 9º Andar, 351, São Paulo, CEP 01246-902, Brazil.
Braz J Microbiol. 2022 Sep;53(3):1339-1344. doi: 10.1007/s42770-022-00779-1. Epub 2022 Jun 11.
New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales was first detected in Brazil in 2014, in a Providencia rettgeri isolate recovered from surveillance swabs in the Southern region. Since then, an increasing number of NDM enzymes have been reported in different species. Nevertheless, comprehensive data on the current epidemiology of NDM-producing Enterobacterales in Brazil are lacking. Therefore, this study reviewed the available information on the status of NDM-producing bacteria in Brazil. The main finding was the diversity of bacteria producing NDM, including Klebsiella, Enterobacter, Morganella, Proteus, Escherichia, and Providencia. Limited data on clonality are available, but a few studies report different clonal backgrounds in NDM-producing K. pneumoniae, likely indicating local outbreaks. Over the years, a rise in the number of reported strains in different locations has been verified; however, different biases may have contributed to this finding. Therefore, a national surveillance study is warranted to identify the actual prevalence and incidence of NDM-producing Enterobacterales in Brazil and their role in patient management and outcome.
2014 年，在巴西南部地区的监测拭子中分离出的弗氏普罗维登斯菌中首次发现了新德里金属β-内酰胺酶（NDM）产生的肠杆菌科。此后，不同种属的 NDM 酶报道数量不断增加。然而，目前仍缺乏巴西产 NDM 肠杆菌科的综合流行情况数据。因此，本研究回顾了巴西产 NDM 细菌的现有信息。主要发现是产生 NDM 的细菌种类多样，包括克雷伯氏菌、肠杆菌、摩根菌、普罗威登斯菌、大肠埃希菌和弗氏普罗维登斯菌。关于克隆性的有限数据，但有一些研究报告称产 NDM 的肺炎克雷伯菌有不同的克隆背景，可能表明存在局部暴发。多年来，不同地点报告的菌株数量有所增加；然而，不同的偏差可能导致了这一发现。因此，有必要进行全国性监测研究，以确定巴西产 NDM 肠杆菌科的实际流行率和发病率，及其在患者管理和预后中的作用。
