• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

风疹 IgG 对 COVID-19 的严重程度有影响吗？：风疹 IgG 与 COVID-19。

Does the rubella immunoglobulin G affect the severity of COVID- 19?  : Rubella immunoglobulin G and COVID- 19.

机构信息

Maternal, Fetal and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Science, Tehran, Iran.

School of Medicine, Tehran University of Medical Science, Tehran, Iran.

出版信息

BMC Microbiol. 2022 Jun 11;22(1):156. doi: 10.1186/s12866-022-02563-5.

DOI:10.1186/s12866-022-02563-5
PMID:35690730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9187882/
Abstract

OBJECTIVE & AIM: The coronavirus disease, so far (COVID-19) has brought about millions of infections and fatalities throughout the world. Our aim was to determine the correlation between rubella IGG titers with the severity COVID-19.  MATERIALS & METHODS: This study was conducted among COVID-19 confirmed patients over 18 years of age. The disease severity levels were categorized by WHO interim guidance. The rubella-specific IgG antibody-titer spectrum was measured (within first 48 h of hospitalization) by enzyme-linked immunosorbent assay (ELISA).

RESULT

In a study of 46 inpatients with varying COVID-19 disease severity (mild, moderate, severe, and critical), we observed a negative correlation between rubella IgG antibody titers and COVID-19 severity (P-Value = 0.017), There was an interaction between COVID-19 vaccination history and rubella IGG on severity COVID-19 (P-Value = 0.0015). There was an interaction between age group under 44 years (including national measles- rubella (MR) vaccination in Iran) and rubella IGG titers on severity COVID-19 too (p-value = 0.014).

CONCLUSION

In conclusion, MR vaccination seems to have a positive effect in reducing the severity of the disease, emphasizing that, the important and separate effect of the IGG rubella (due to natural or extrinsic immunity) titers is determining.

摘要

目的与目标

到目前为止（COVID-19），冠状病毒疾病已在全球范围内导致数百万人感染和死亡。我们的目的是确定风疹 IgG 滴度与 COVID-19 严重程度之间的相关性。

材料与方法

这项研究是在 18 岁以上的 COVID-19 确诊患者中进行的。根据世界卫生组织的临时指南，将疾病严重程度分为几类。通过酶联免疫吸附试验（ELISA）测量风疹特异性 IgG 抗体滴度谱（住院后 48 小时内）。

结果

在一项对 46 名不同 COVID-19 疾病严重程度（轻度、中度、重度和危重度）住院患者的研究中，我们观察到风疹 IgG 抗体滴度与 COVID-19 严重程度之间呈负相关（P 值=0.017）。COVID-19 疫苗接种史与风疹 IGG 对 COVID-19 严重程度之间存在交互作用（P 值=0.0015）。年龄在 44 岁以下的年龄组（包括伊朗的国家麻疹-风疹（MR）疫苗接种）与风疹 IGG 滴度对 COVID-19 严重程度也存在交互作用（p 值=0.014）。

结论

总之，MR 疫苗接种似乎对减轻疾病严重程度有积极影响，这强调了风疹 IgG （由于自然或外在免疫）滴度的重要和独立作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad1/9188065/a5443749c270/12866_2022_2563_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad1/9188065/74f9ab30abb7/12866_2022_2563_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad1/9188065/c07dabf7e49b/12866_2022_2563_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad1/9188065/a5443749c270/12866_2022_2563_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad1/9188065/74f9ab30abb7/12866_2022_2563_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad1/9188065/c07dabf7e49b/12866_2022_2563_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad1/9188065/a5443749c270/12866_2022_2563_Fig3_HTML.jpg

相似文献

1
Does the rubella immunoglobulin G affect the severity of COVID- 19?  : Rubella immunoglobulin G and COVID- 19.风疹 IgG 对 COVID-19 的严重程度有影响吗？：风疹 IgG 与 COVID-19。
BMC Microbiol. 2022 Jun 11;22(1):156. doi: 10.1186/s12866-022-02563-5.
2
Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients.分析新冠肺炎康复患者的麻疹-腮腺炎-风疹（MMR）滴度。
mBio. 2020 Nov 20;11(6):e02628-20. doi: 10.1128/mBio.02628-20.
3
Persistence of Anti-Rubella Immunoglobulin G Antibody Titers in Young Adults Involved in a Short-Term Periodic Immunization in Japan.参与日本短期定期免疫接种的年轻成年人中抗风疹免疫球蛋白G抗体滴度的持续性
Jpn J Infect Dis. 2021 Sep 22;74(5):473-476. doi: 10.7883/yoken.JJID.2020.542. Epub 2021 Feb 26.
4
Prospective Study of Live Attenuated Vaccines for Patients with Nephrotic Syndrome Receiving Immunosuppressive Agents.肾病综合征患者接受免疫抑制剂治疗时使用活疫苗的前瞻性研究。
J Pediatr. 2018 May;196:217-222.e1. doi: 10.1016/j.jpeds.2017.12.061. Epub 2018 Feb 28.
5
Rubella virus-specific humoral immune responses and their interrelationships before and after a third dose of measles-mumps-rubella vaccine in women of childbearing age.风疹病毒特异性体液免疫应答及其在育龄妇女接种麻疹-腮腺炎-风疹疫苗第三剂前后的相互关系。
Vaccine. 2020 Jan 29;38(5):1249-1257. doi: 10.1016/j.vaccine.2019.11.004. Epub 2019 Nov 12.
6
Detection of serum antibodies against measles, mumps and rubella after primary measles, mumps and rubella (MMR) vaccination in children.检测儿童原发性麻疹、腮腺炎和风疹（MMR）疫苗接种后针对麻疹、腮腺炎和风疹的血清抗体。
Arch Iran Med. 2013 Jan;16(1):38-41.
7
IgG antibody titers against SARS-CoV-2 nucleocapsid protein correlate with the severity of COVID-19 patients.针对严重急性呼吸综合征冠状病毒 2 核衣壳蛋白的 IgG 抗体滴度与 COVID-19 患者的严重程度相关。
BMC Microbiol. 2021 Dec 18;21(1):351. doi: 10.1186/s12866-021-02401-0.
8
Different Profiles of Antibodies and Cytokines Were Found Between Severe and Moderate COVID-19 Patients.严重和中度 COVID-19 患者的抗体和细胞因子谱存在差异。
Front Immunol. 2021 Aug 19;12:723585. doi: 10.3389/fimmu.2021.723585. eCollection 2021.
9
Prevalence of anti-rubella, anti-measles and anti-mumps IgG antibodies in neonates and pregnant women in Catalonia (Spain) in 2013: susceptibility to measles increased from 2003 to 2013.2013年西班牙加泰罗尼亚地区新生儿及孕妇中抗风疹、抗麻疹和抗腮腺炎IgG抗体的流行情况：2003年至2013年麻疹易感性增加。
Eur J Clin Microbiol Infect Dis. 2015 Jun;34(6):1161-71. doi: 10.1007/s10096-015-2339-4. Epub 2015 Feb 10.
10
[Microtiter enzyme-linked immunosorbent assay for rubella antibodies in human sera--analysis by parallel line assay method].[人血清风疹抗体微量酶联免疫吸附测定——平行线分析法分析]
Kansenshogaku Zasshi. 1992 Aug;66(8):1075-83. doi: 10.11150/kansenshogakuzasshi1970.66.1075.

本文引用的文献

1
A Review on Rubella Vaccine: Iran (1975-2010).风疹疫苗综述：伊朗（1975-2010）。
Arch Razi Inst. 2021 Jul;76(2):167-192. doi: 10.22092/ari.2021.353242.1594. Epub 2021 Jul 1.
2
Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study.医护人员近期接种 MMR 疫苗与新冠病毒（Covid-19）：一项基于阴性对照的病例对照研究。
Vaccine. 2021 Jul 22;39(32):4414-4418. doi: 10.1016/j.vaccine.2021.06.045. Epub 2021 Jun 22.
3
Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?
既往麻疹、腮腺炎和风疹疫苗接种是否有助于对 COVID-19 抗原的抗体反应？
Iran J Immunol. 2021 Mar;18(1):47-53. doi: 10.22034/iji.2021.87990.1843.
4
Accountability and transparency are vital in a pandemic response.在应对疫情时，问责制和透明度至关重要。
J Gen Fam Med. 2020 Nov 11;22(2):113-114. doi: 10.1002/jgf2.401. eCollection 2021 Mar.
5
Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations.对免疫记录的探索性分析表明，近期接种过非 COVID-19 疫苗的个体中 SARS-CoV-2 感染率降低。
Sci Rep. 2021 Feb 26;11(1):4741. doi: 10.1038/s41598-021-83641-y.
6
Reply to Marakasova and Baranova, "MMR Vaccine and COVID-19: Measles Protein Homology May Contribute to Cross-Reactivity or to Complement Activation Protection".对马拉卡索娃和巴拉诺娃的回复，“MMR疫苗与COVID-19：麻疹蛋白同源性可能导致交叉反应或补体激活保护”
mBio. 2021 Feb 2;12(1):e03682-20. doi: 10.1128/mBio.03682-20.
7
MMR Vaccine and COVID-19: Measles Protein Homology May Contribute to Cross-Reactivity or to Complement Activation Protection.麻腮风疫苗与新冠病毒：麻疹蛋白同源性可能导致交叉反应或补体激活保护作用。
mBio. 2021 Feb 2;12(1):e03447-20. doi: 10.1128/mBio.03447-20.
8
Measles and Rubella during COVID-19 Pandemic: Future Challenges in Japan.COVID-19 大流行期间的麻疹和风疹：日本未来的挑战。
Int J Environ Res Public Health. 2020 Dec 22;18(1):9. doi: 10.3390/ijerph18010009.
9
Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients.分析新冠肺炎康复患者的麻疹-腮腺炎-风疹（MMR）滴度。
mBio. 2020 Nov 20;11(6):e02628-20. doi: 10.1128/mBio.02628-20.
10
MMR Vaccination: A Potential Strategy to Reduce Severity and Mortality of COVID-19 Illness.麻疹、腮腺炎、风疹联合疫苗接种：一种降低新冠病毒疾病严重程度和死亡率的潜在策略。
Am J Med. 2021 Feb;134(2):153-155. doi: 10.1016/j.amjmed.2020.10.003. Epub 2020 Oct 23.