Department of Pulmonology, Shree Birendra Hospital, Chhauni, Kathmandu, Nepal.
Department of Internal Medicine, Shree Birendra Hospital, Chhauni, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2022 Jun 1;60(250):541-545. doi: 10.31729/jnma.7512.
Acute exacerbation of chronic obstructive pulmonary disease is a life-threatening condition triggered by infections or non-infectious agents. Antibiotics use in such cases prevents severe deterioration and treatment failure. Past studies have shown inappropriate use of antibiotics in different health care settings. The objective of this study was to find out the prevalence of antibiotics use in patients with acute exacerbation of chronic obstructive pulmonary disease in the Department of Internal Medicine of a tertiary care centre.
A descriptive cross-sectional study was conducted among patients with acute exacerbation of Chronic Obstructive Pulmonary Disease admitted to Department of Internal Medicine of a tertiary care centre from 12th February, 2022 to 15th April, 2022 after taking ethical clearance from Institutional Review Committee (Reference number: 417). Convenience sampling was done. Data analysis was done using the Statistical Package for the Social Sciences version 23.0. Point estimate at 95% Confidence Interval was calculated along with frequency and percentage for binary data along with median and interquartile range for continuous data.
The prevalence of antibiotics use among study participants was 106 (98.15%) (95.61-100 at a 95% Confidence Interval). Penicillin 82 (75.93%) was the most commonly used antibiotics group.
The use of antibiotics in acute exacerbation of chronic obstructive pulmonary disease was higher as compared to other similar studies.
anti-bacterial agents; chronic obstructive pulmonary disease; guideline adherence.
慢性阻塞性肺疾病急性加重是一种由感染或非感染性因素引发的危及生命的病症。在这种情况下使用抗生素可以防止病情严重恶化和治疗失败。过去的研究表明，在不同的医疗保健环境中，抗生素的使用存在不当情况。本研究的目的是了解三级保健中心内科慢性阻塞性肺疾病急性加重患者使用抗生素的情况。
在获得机构审查委员会（参考号：417）的伦理批准后，于 2022 年 2 月 12 日至 2022 年 4 月 15 日，对三级保健中心内科收治的慢性阻塞性肺疾病急性加重患者进行了一项描述性横断面研究。采用便利抽样法。使用社会科学统计软件包（SPSS）版本 23.0 进行数据分析。计算了 95%置信区间的点估计值，以及二分类数据的频率和百分比、连续数据的中位数和四分位距。
研究参与者中抗生素使用的比例为 106 例（98.15%）（95.61-100 的 95%置信区间）。青霉素 82 例（75.93%）是最常用的抗生素组。
与其他类似研究相比，慢性阻塞性肺疾病急性加重患者使用抗生素的比例更高。
抗菌剂；慢性阻塞性肺疾病；指南依从性。
