在一家三级保健中心进行甲状腺功能检查的婴儿中的先天性甲状腺功能减退症：一项描述性的横断面研究。

Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

机构信息

Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Buddha Road, Dharan, Nepal.

Department of Paediatrics and Adolescents Medicine, B.P. Koirala Institute of Health Sciences, Buddha Road, Dharan, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2022 Jun 1;60(250):503-506. doi: 10.31729/jnma.7505.

DOI:10.31729/jnma.7505

PMID:35690974

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9275452/

Abstract

INTRODUCTION

Congenital hypothyroidism is the most preventable and treatable cause of mental retardation in newborns and infants. Screening for congenital hypothyroidism in newborns and infants is not a routine practice in our part of the world. This study aimed to find out the prevalence of congenital hypothyroidism among infants undergoing thyroid function test in a tertiary care centre.

METHODS

A descriptive cross-sectional study was done in the Department of Biochemistry, from laboratory records starting 14th April, 2013 to 13th April, 2020 after obtaining ethical clearance from the Institutional Review Committee (Reference number: 1502/019). Data of infants whose thyroid function tests were performed were obtained using convenience sampling. Thyroid-stimulating hormone was categorised per the European Society of Paediatric Endocrinology guidelines. Data were entered and analysed using Microsoft Excel 2011 and the Statistical Package for the Social Sciences version 11.5. Point estimate at a 95% Confidence Interval was calculated along with frequency and percentages for binary data.

RESULTS

Among 1243 infants, 56 (4.50%) (3.35-5.65 at 95% Confidence Interval) infants were diagnosed with congenital hypothyroidism.

CONCLUSIONS

The prevalence of congenital hypothyroidism was higher than other studies done in similar settings. An unexpected finding of treatment-induced hyperthyroidism was observed, indicating a lack of regular and timely follow-up of infants diagnosed with congenital hypothyroidism.

KEYWORDS

congenital hypothyroidism; Nepal; newborn screening; prevalence.

摘要

简介

先天性甲状腺功能减退症是导致新生儿和婴儿智力障碍最可预防和可治疗的原因。在我们所处的世界，对新生儿和婴儿进行先天性甲状腺功能减退症筛查并非常规做法。本研究旨在了解在一家三级保健中心进行甲状腺功能检测的婴儿中先天性甲状腺功能减退症的患病率。

方法

这是一项在获得机构审查委员会（参考编号：1502/019）伦理批准后，于 2013 年 4 月 14 日至 2020 年 4 月 13 日在生化科进行的描述性横断面研究。使用便利抽样法获取接受甲状腺功能检测的婴儿的实验室记录数据。根据欧洲儿科内分泌学会指南对促甲状腺激素进行分类。使用 Microsoft Excel 2011 和社会科学统计软件包版本 11.5 输入和分析数据。计算了 95%置信区间的点估计值，以及二项数据的频率和百分比。