Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Nepal.
Universal College of Medical Sciences, Bhairahawa, Nepal.
JNMA J Nepal Med Assoc. 2021 Aug 12;59(240):783-786. doi: 10.31729/jnma.6809.
Thyroid hormones have a major influence on synthesis, mobilization and metabolism of lipids. Hypothyroidism accounts for a notable cause of secondary dyslipidemia. This can increase the risk for cardiovascular morbidity and mortality. This study was performed to find out the prevalence of lipid profile abnormalities in newly diagnosed primary hypothyroid states.
This descriptive cross-sectional study was conducted among 71 patients in the context of newly diagnosed primary hypothyroidism patients visiting outpatient department of internal medicine from 9th December 2018 to 30th June 2020 after taking ethical clearance from Institutional Review Committee. Case screening for lipid profile changes was performed at the time of diagnosis of primary hypothyroidism. A convenience sampling method was used. Data entry and descriptive analysis were done in Statistical Package for the Social Sciences version 16.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.
In this study including 71 cases of newly diagnosed primary hypothyroidism, 49 (69.0%) (95% Confidence Interval= 58.24-79.76) had abnormal lipid profiles. Among them, 5 (38.5%) out of 13 (18.3%) cases of subclinical hypothyroidism and 44 (75.9%) out of 58 (81.7%) cases of overt hypothyroidism had abnormal lipid profiles.
The prevalence of abnormal lipid profile parameters was similar to the study done in various studies in similar settings except for high-density lipid which showed both similarity and dissimilarity with other studies. Our study suggested that all newly diagnosed cases of primary hypothyroidism are to be investigated for dyslipidemia thus ensuring early treatment and prevention of complications.
甲状腺激素对脂质的合成、动员和代谢有重要影响。甲状腺功能减退症是继发性血脂异常的一个显著原因。这会增加心血管发病率和死亡率的风险。本研究旨在发现新诊断的原发性甲状腺功能减退症患者的血脂谱异常的患病率。
这是一项描述性的横断面研究，在 2018 年 12 月 9 日至 2020 年 6 月 30 日期间，在获得机构审查委员会的伦理批准后，对 71 例新诊断的原发性甲状腺功能减退症患者进行了门诊就诊。在诊断原发性甲状腺功能减退症时，对血脂谱变化进行了病例筛查。使用便利抽样法。数据录入和描述性分析在社会科学统计软件包 16.0 中进行。计算了 95%置信区间的点估计值，以及二项数据的频率和比例。
在这项包括 71 例新诊断的原发性甲状腺功能减退症的研究中，49 例（69.0%）（95%置信区间=58.24-79.76）有异常的血脂谱。其中，13 例（18.3%）亚临床甲状腺功能减退症中有 5 例（38.5%），58 例（81.7%）临床甲状腺功能减退症中有 44 例（75.9%）有异常的血脂谱。
异常血脂谱参数的患病率与类似环境下的其他研究相似，除高密度脂蛋白外，其他研究与其他研究既有相似之处，也有不同之处。我们的研究表明，所有新诊断的原发性甲状腺功能减退症患者都应进行血脂异常检查，从而确保早期治疗和预防并发症。
