胺碘酮对血清脂质、脂蛋白脂肪酶及肝甘油三酯脂肪酶的影响。

Effect of amiodarone on serum lipids, lipoprotein lipase, and hepatic triglyceride lipase.

作者信息

Kasim S E, Bagchi N, Brown T R, Khilnani S

出版信息

Endocrinology. 1987 May;120(5):1991-5. doi: 10.1210/endo-120-5-1991.

DOI:10.1210/endo-120-5-1991

Abstract

We have determined the effects of chronic amiodarone treatment on lipid metabolism and compared them with those of hypothyroidism in the rat. Serum triglyceride was lower in both amiodarone-treated and hypothyroid rats; total cholesterol was higher in hypothyroid rats, and serum high density lipoprotein cholesterol remained unchanged. Amiodarone increased adipose tissue lipoprotein lipase activity. Hepatic triglyceride lipase activity was decreased in both hypothyroid and amiodarone-treated groups. The effects of amiodarone on serum triglyceride and adipose tissue lipoprotein lipase were reversed by concomitant administration of T3. The activity of hepatic triglyceride lipase, however, was not increased. Our findings indicate that amiodarone causes marked changes in lipid metabolism which are similar to those found in hypothyroidism.

摘要

我们已经确定了慢性胺碘酮治疗对大鼠脂质代谢的影响，并将其与甲状腺功能减退的影响进行了比较。胺碘酮治疗组和甲状腺功能减退组大鼠的血清甘油三酯均较低；甲状腺功能减退组大鼠的总胆固醇较高，而血清高密度脂蛋白胆固醇保持不变。胺碘酮增加了脂肪组织脂蛋白脂肪酶的活性。甲状腺功能减退组和胺碘酮治疗组的肝甘油三酯脂肪酶活性均降低。同时给予T3可逆转胺碘酮对血清甘油三酯和脂肪组织脂蛋白脂肪酶的影响。然而，肝甘油三酯脂肪酶的活性并未增加。我们的研究结果表明，胺碘酮会引起脂质代谢的显著变化，这些变化与甲状腺功能减退时发现的变化相似。