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希氏斑疹伤寒样综合征继发于圆斑蝰蛇咬伤。

Development of Wunderlich syndrome following a Russell's viper bite.

机构信息

Manian Medical Centre, Erode, Tamil Nadu, India.

The Poison Control Center, Children's Hospital of Philadelphia, USA.

出版信息

Toxicon. 2022 Aug;215:11-16. doi: 10.1016/j.toxicon.2022.06.004. Epub 2022 Jun 9.

DOI:10.1016/j.toxicon.2022.06.004
PMID:35691405
Abstract

Snakebite envenomation is a high priority neglected tropical disease that predominantly affects rural communities living in developing countries. Due to myriad of complications including coagulopathies, neurotoxicity, nephrotoxicity and local tissue destruction, treating snakebite victims is a major challenge for clinicians. Russell's viper (Daboia russelii) is one of the 'Big Four' venomous snakes in India, and it is responsible for the most snakebite-induced deaths and disabilities. Acute kidney injury occurs frequently following Russell's viper bites and it is a critical factor contributing to disabilities, deaths and excessive treatment costs. In addition to commonly observed envenomation effects, Russell's viper bites induce some rare complications such as priapism, sialolithiasis and splenic rupture. Here, we report a case of Wunderlich syndrome that developed in a 22-year-old male following a Russell's viper bite. The patient displayed severe coagulopathies, abdominal tenderness, and hypotension. Notably, a peri-nephric haematoma was identified through ultrasound and computerised tomographic imaging. The haemorrhage was successfully treated using angioembolisation, and the patient recovered without any difficulties. Although a clinical condition such as this is rare, it is important to create awareness among treating clinicians about its occurrence, diagnosis and clinical management.

摘要

蛇伤是一种被高度忽视的热带病,主要影响生活在发展中国家的农村社区。由于包括凝血功能障碍、神经毒性、肾毒性和局部组织破坏在内的多种并发症,治疗蛇伤患者对临床医生来说是一个重大挑战。圆斑蝰(Daboia russelii)是印度“四大毒蛇”之一,是导致蛇伤所致死亡和残疾的主要原因。圆斑蝰咬伤后常发生急性肾损伤,是导致残疾、死亡和过度治疗费用的关键因素。除了常见的中毒效应外,圆斑蝰咬伤还会引起一些罕见的并发症,如阴茎异常勃起、涎石症和脾破裂。在此,我们报告一例 22 岁男性因圆斑蝰咬伤后发生 Wunderlich 综合征的病例。患者表现为严重的凝血功能障碍、腹痛和低血压。值得注意的是,通过超声和计算机断层成像发现了肾周血肿。通过血管栓塞成功治疗了出血,患者没有任何困难地康复了。尽管这种临床情况很少见,但重要的是要让治疗医生了解其发生、诊断和临床管理。

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