利用噬菌体衍生的碳水化合物解聚酶对抗传染病。
Exploiting phage-derived carbohydrate depolymerases for combating infectious diseases.
作者信息
Oliveira Hugo, Drulis-Kawa Zuzanna, Azeredo Joana
机构信息
CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal; LABBELS - Associate Laboratory, Braga/Guimarães, Portugal; ESCMID Study Group for Non-traditional Antibacterial Therapy (ESGNTA); ESCMID Study Group for Biofilms (ESGB).
Department of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland; ESCMID Study Group for Non-traditional Antibacterial Therapy (ESGNTA).
出版信息
Trends Microbiol. 2022 Aug;30(8):707-709. doi: 10.1016/j.tim.2022.05.002. Epub 2022 Jun 9.
Bacteria are protected against the immune system of their human hosts, as well as against predators such as phages, by expressing diverse surface carbohydrates. Some phages produce specialized depolymerases which can degrade those carbohydrates. Here, we discuss the biological role of depolymerases and how they can be exploited to develop new therapeutic strategies against pathogens.
细菌通过表达多种表面碳水化合物来抵御人类宿主的免疫系统以及噬菌体等捕食者。一些噬菌体产生能够降解这些碳水化合物的特异性解聚酶。在此，我们讨论解聚酶的生物学作用以及如何利用它们来开发针对病原体的新治疗策略。
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