Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
Beijing Municipal Geriatric Medical Research Center, Beijing, 100053, China.
Transl Stroke Res. 2023 Dec;14(6):803-805. doi: 10.1007/s12975-022-01048-x. Epub 2022 Jun 13.
Ischemic stroke is one of the leading causes of mortality and disability worldwide. Currently, options for ischemic stroke clinical therapy remain limited to intravenous thrombolysis and thrombectomy, which can only be applied to a minority of patients due to narrow therapeutic time window. Therefore, the discovery of new therapeutic targets and biomarkers is of great significance for ischemic stroke therapy. Long non-coding RNAs (lncRNAs) are the most extensive ncRNA transcripts and play critical roles in different kinds of diseases. Accumulative evidence suggests that lncRNAs are widely involved in multiple pathophysiological processes of ischemic stroke, highlighting their potential role as ischemic stroke therapeutic targets. Moreover, the significantly altered expression of lncRNAs in circulation of ischemic stroke patients reveals that they may serve as diagnostic, therapeutic, and prognosis biomarkers for ischemic stroke. In this commentary, we provide an overview of the roles of lncRNAs in the pathophysiology of ischemic stroke and discuss the opportunities of lncRNAs in the diagnosis and treatment of ischemic stroke. In addition, the challenges for the clinical translation of lncRNAs in ischemic stroke are also discussed.
缺血性脑卒中是全球范围内导致死亡和残疾的主要原因之一。目前，缺血性脑卒中的临床治疗选择仍然局限于静脉溶栓和血栓切除术，但由于治疗时间窗狭窄，这些方法只能应用于少数患者。因此，发现新的治疗靶点和生物标志物对于缺血性脑卒中的治疗具有重要意义。长链非编码 RNA（lncRNA）是最广泛的 ncRNA 转录物，在各种疾病中发挥着关键作用。越来越多的证据表明，lncRNA 广泛参与缺血性脑卒中的多种病理生理过程，突出了它们作为缺血性脑卒中治疗靶点的潜力。此外，缺血性脑卒中患者循环中 lncRNA 的显著改变表达表明，它们可能作为缺血性脑卒中的诊断、治疗和预后生物标志物。在本评论中，我们概述了 lncRNA 在缺血性脑卒中病理生理学中的作用，并讨论了 lncRNA 在缺血性脑卒中诊断和治疗中的机遇。此外，还讨论了 lncRNA 在缺血性脑卒中临床转化中的挑战。
