[Personalized therapy for on initial treatment: the initial treatment is the decisive battle].

As widespread eradication treatment continues, the rate of () antibiotic resistance is increasing. Together with host CYP2C19 gene polymorphisms, coccoid transformation, patient compliance, irregular treatment regimens or empirical repeated eradication therapy by physician, eradication rates have gradually decreased. Personalized treatment is an effective measure to achieve successful eradication of in the initial treatment. With the first approval of molecular diagnostic kit for clarithromycin resistance in China and the updated definition of refractory infection by the American Gastroenterological Association (AGA), the personalized treatment of guided by antibiotic resistance genotype detection in initial treatment, that follows the latest international consensus and guidelines, conforms to the national situation and surpasses the international standards, has come to the forefront.