Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, China.
Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2022 May 25;13:896369. doi: 10.3389/fendo.2022.896369. eCollection 2022.
The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study.
The single nucleotide polymorphisms (SNPs) associated with snoring were retrieved from the UK biobank cohort with 314,449 participants (117,812 cases and 196,637 controls). The summary statistics of ED were obtained from the European ancestry with 223,805 subjects (6,175 cases and 217,630 controls). Single-variable Mendelian randomization (MR) and multivariable MR were used to assess the causal relationship between snoring and ED.
Snoring increases the risk of ED (Odds ratio [OR] = 3.45, 95% confidence interval [CI] = 1.68 - 7.09, < 0.001) in the inverse variance weighting estimator. In sensitivity analyses, the ORs for the weighted median, MR robust adjusted profile score, and MR Pleiotropy Residual Sum and Outlier approach, MR-Egger, and maximum likelihood method are 5.70 (95% CI = 1.19 - 27.21, < 0.05), 3.14 (95% CI = 1.01 - 9.72, < 0.05), 3.11 (95% CI = 1.63 - 5.91, < 0.01), 1.23 (95% CI = 0.01 - 679.73, > 0.05), and 3.59 (95% CI = 1.07 - 12.00, < 0.05), respectively. No heterogeneity and pleiotropy are observed ( for MR-Egger intercept = 0.748; for global test = 0.997; for Cochran's Q statistics > 0.05). After adjusting for total cholesterol, triglyceride, low-density lipoprotein, and cigarette consumption, the ORs for ED are 5.75 (95% CI = 1.80 - 18.34, < 0.01), 4.16 (95% CI = 1.10 - 15.81, < 0.05), 5.50 (95% CI = 1.62 - 18.69, < 0.01), and 2.74 (95% CI = 1.06 - 7.10, < 0.05), respectively.
This study provides genetic evidence supporting the causal role of snoring in ED.
打鼾与勃起功能障碍（ED）之间的关联在多项观察性研究中并不一致。为了阐明打鼾与 ED 之间的因果关联，我们进行了这项两样本孟德尔随机化研究。
从 UK Biobank 队列中检索到与打鼾相关的单核苷酸多态性（SNP），该队列有 314449 名参与者（117812 例病例和 196637 例对照）。ED 的汇总统计数据来自欧洲血统的 223805 名受试者（6175 例病例和 217630 例对照）。单变量孟德尔随机化（MR）和多变量 MR 用于评估打鼾与 ED 之间的因果关系。
在逆方差加权估计中，打鼾增加了 ED 的风险（比值比[OR] = 3.45，95%置信区间[CI] = 1.68-7.09，<0.001）。在敏感性分析中，加权中位数、MR 稳健调整的累积和外向量得分、MR-Pleiotropy 残差和异常值方法、MR-Egger 和最大似然法的 OR 分别为 5.70（95%CI = 1.19-27.21，<0.05）、3.14（95%CI = 1.01-9.72，<0.05）、3.11（95%CI = 1.63-5.91，<0.01）、1.23（95%CI = 0.01-679.73，>0.05）和 3.59（95%CI = 1.07-12.00，<0.05）。未观察到异质性和多效性（MR-Egger 截距为 0.748；全局检验为 0.997；Cochran's Q 统计量>0.05）。在校正总胆固醇、甘油三酯、低密度脂蛋白和吸烟量后，ED 的 OR 分别为 5.75（95%CI = 1.80-18.34，<0.01）、4.16（95%CI = 1.10-15.81，<0.05）、5.50（95%CI = 1.62-18.69，<0.01）和 2.74（95%CI = 1.06-7.10，<0.05）。
本研究提供了遗传证据，支持打鼾与 ED 之间存在因果关系。
