Kazakov O V, Kabakov A V, Poveshchenko A F, Cherkas V N, Bodrova N R
Research Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2025 May;179(1):81-85. doi: 10.1007/s10517-025-06433-8. Epub 2025 Jul 18.
A histological study of structural changes in the thymus of female Wistar rats with chemically induced breast cancer (BC) after photodynamic therapy (PDT) and a combination of PDT and surgical treatment was conducted. After PDT, the thymus showed restoration of the cortical and medullary substance areas, as well as glandular tissue, to the values of the intact control in comparison with the pathological control (BC without treatment). PDT influences both positive and negative selection processes and the activity of T-lymphocyte differentiation processes (the number of epithelial cells and macrophages increases, the number of cells with pyknotic nuclei in the cortical and medullary substance decreases). In the cortico-medullary zone of the thymus, the number of small and medium lymphocytes increases, which may indicate an increase in lymphocyte migration from the thymus. After PDT and subsequent resection of a BC, structural changes in the thymus may indicate a decrease in its lymphopoietic function, activity of both positive and negative T-cell selection processes, as well as a decrease in the activity of T-lymphocyte differentiation processes and their migration from the thymus.
对化学诱导乳腺癌（BC）的雌性Wistar大鼠在光动力疗法（PDT）以及PDT与手术治疗联合应用后胸腺结构变化进行了组织学研究。与病理对照组（未治疗的BC）相比，PDT后，胸腺的皮质和髓质物质区域以及腺组织恢复到完整对照组的值。PDT影响阳性和阴性选择过程以及T淋巴细胞分化过程的活性（上皮细胞和巨噬细胞数量增加，皮质和髓质物质中核固缩细胞数量减少）。在胸腺的皮质-髓质区，中小淋巴细胞数量增加，这可能表明从胸腺迁移的淋巴细胞增多。在PDT及随后切除BC后，胸腺的结构变化可能表明其淋巴细胞生成功能、T细胞阳性和阴性选择过程的活性降低，以及T淋巴细胞分化过程及其从胸腺迁移的活性降低。
