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质子治疗中周围器官等效剂量估计程序

Peripheral Organ Equivalent Dose Estimation Procedure in Proton Therapy.

作者信息

Domingo Carles, Lagares Juan Ignacio, Romero-Expósito Maite, Sánchez-Nieto Beatriz, Nieto-Camero Jaime J, Terrón Jose Antonio, Irazola Leticia, Dasu Alexandru, Sánchez-Doblado Francisco

机构信息

Departament de Fisica, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Unidad de Aplicaciones Médicas, Departamento de Tecnología, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.

出版信息

Front Oncol. 2022 May 25;12:882476. doi: 10.3389/fonc.2022.882476. eCollection 2022.

DOI:10.3389/fonc.2022.882476
PMID:35692801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9176390/
Abstract

The aim of this work is to present a reproducible methodology for the evaluation of total equivalent doses in organs during proton therapy facilities. The methodology is based on measuring the dose equivalent in representative locations inside an anthropomorphic phantom where photon and neutron dosimeters were inserted. The Monte Carlo simulation was needed for obtaining neutron energy distribution inside the phantom. The methodology was implemented for a head irradiation case in the passive proton beam of iThemba Labs (South Africa). Thermoluminescent dosimeter (TLD)-600 and TLD-700 pairs were used as dosimeters inside the phantom and GEANT code for simulations. In addition, Bonner sphere spectrometry was performed inside the treatment room to obtain the neutron spectra, some relevant neutron dosimetric quantities per treatment Gy, and a percentual distribution of neutron fluence and ambient dose equivalent in four energy groups, at two locations. The neutron spectrum at one of those locations was also simulated so that a reasonable agreement between simulation and measurement allowed a validation of the simulation. Results showed that the total out-of-field dose equivalent inside the phantom ranged from 1.4 to 0.28 mSv/Gy, mainly due to the neutron contribution and with a small contribution from photons, 10% on average. The order of magnitude of the equivalent dose in organs was similar, displaying a slow reduction in values as the organ is farther from the target volume. These values were in agreement with those found by other authors in other passive beam facilities under similar irradiation and measurement conditions.

摘要

这项工作的目的是提出一种可重复的方法,用于评估质子治疗设施中器官内的总等效剂量。该方法基于测量在插入了光子和中子剂量计的人体模型内代表性位置处的剂量当量。需要进行蒙特卡罗模拟以获得模型内的中子能量分布。该方法在南非iThemba实验室的被动质子束头部照射案例中得到了应用。热释光剂量计(TLD)-600和TLD-700对被用作模型内的剂量计,并使用GEANT代码进行模拟。此外,在治疗室内进行了邦纳球谱测量,以获得中子能谱、每次治疗Gy的一些相关中子剂量学量,以及在两个位置四个能量组中的中子注量和环境剂量当量的百分比分布。还对其中一个位置的中子能谱进行了模拟,以便模拟与测量之间的合理一致性能够验证模拟结果。结果表明,模型内的总野外剂量当量范围为1.4至0.28 mSv/Gy,主要是由于中子的贡献,光子的贡献较小,平均为10%。器官内等效剂量的量级相似,随着器官离靶体积越远,其值呈缓慢下降趋势。这些值与其他作者在其他被动束设施中在类似照射和测量条件下发现的值一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/12514d741f5a/fonc-12-882476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/e4c1f86018ad/fonc-12-882476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/2702d377cfe9/fonc-12-882476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/eeb86e6aa01f/fonc-12-882476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/deb03914e040/fonc-12-882476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/3546dcfdabcf/fonc-12-882476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/0c19eda5b8bf/fonc-12-882476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/12514d741f5a/fonc-12-882476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/e4c1f86018ad/fonc-12-882476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/2702d377cfe9/fonc-12-882476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/eeb86e6aa01f/fonc-12-882476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/deb03914e040/fonc-12-882476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/3546dcfdabcf/fonc-12-882476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/0c19eda5b8bf/fonc-12-882476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7331/9176390/12514d741f5a/fonc-12-882476-g007.jpg

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本文引用的文献

1
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020:全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
2
Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.质子治疗与X射线治疗纵隔恶性淋巴瘤后的继发恶性肿瘤风险:一项胸部器官特异性癌症风险的比较建模研究
Front Oncol. 2020 Jul 7;10:989. doi: 10.3389/fonc.2020.00989. eCollection 2020.
3
在小儿脑癌治疗中,包括成像程序在内的光子和质子治疗技术的完整患者暴露情况。
Front Oncol. 2023 Sep 19;13:1222800. doi: 10.3389/fonc.2023.1222800. eCollection 2023.
4
A Prototype Scintillator Real-Time Beam Monitor for Ultra-high Dose Rate Radiotherapy.一种用于超高剂量率放射治疗的闪烁体实时束流监测仪原型。
ArXiv. 2024 Mar 8:arXiv:2305.15306v3.
External photon radiation treatment for prostate cancer: Uncomplicated and cancer-free control probability assessment of 36 plans.
前列腺癌的外部光子放射治疗:36 个计划的无并发症和无癌症控制概率评估。
Phys Med. 2019 Oct;66:88-96. doi: 10.1016/j.ejmp.2019.09.076. Epub 2019 Sep 29.
4
Long-Term Follow-up of Patients Treated at a Single Institution Using a Passively Scattered Proton Beam; Observations Around the Occurrence of Second Malignancies.单中心使用被动散射质子束治疗患者的长期随访;二次恶性肿瘤发生情况观察。
Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):680-685. doi: 10.1016/j.ijrobp.2018.10.022. Epub 2018 Oct 27.
5
COMPARISON OF RESPONSE OF PASSIVE DOSIMETRY SYSTEMS IN SCANNING PROTON RADIOTHERAPY-A STUDY USING PAEDIATRIC ANTHROPOMORPHIC PHANTOMS.扫描质子放射治疗中被动剂量测定系统响应的比较——一项使用儿科人体模型的研究
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6
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7
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Phys Med. 2017 Oct;42:345-352. doi: 10.1016/j.ejmp.2017.03.018. Epub 2017 Mar 31.
8
Improving the neutron-to-photon discrimination capability of detectors used for neutron dosimetry in high energy photon beam radiotherapy.提高用于高能光子束放射治疗中中子剂量测定的探测器的中子与光子鉴别能力。
Appl Radiat Isot. 2016 Sep;115:49-54. doi: 10.1016/j.apradiso.2016.06.009. Epub 2016 Jun 9.
9
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10
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