Adams R L, Davis T, Rinaldi A, Eason R
Eur J Biochem. 1987 May 15;165(1):107-15. doi: 10.1111/j.1432-1033.1987.tb11200.x.
The dinucleotide CpG is deficient in (A + T)-rich regions of vertebrate DNA in both coding and non-coding sequences and there is a corresponding increase above expectation in the occurrence of TpG and CpA. By contrast in (G + C)-rich regions no deficiency of CpG is found. Such (G + C)-rich sequences, containing the expected number of CpG dinucleotides, alternate along the genome with (A + T)-rich sequences which have a lower than expected CpG content. The G + C content of vertebrate DNA can oscillate with a period of 150-200 bp and this may be a factor in positioning nucleosomes. The role of mutagenesis in loss of CpG and increase of A + T, particularly in non-coding regions, is discussed.
在脊椎动物DNA的编码和非编码序列中，富含（A + T）的区域二核苷酸CpG含量不足，相应地，TpG和CpA的出现频率高于预期。相比之下，在富含（G + C）的区域未发现CpG含量不足。这些富含（G + C）的序列，含有预期数量的CpG二核苷酸，与富含（A + T）且CpG含量低于预期的序列沿着基因组交替出现。脊椎动物DNA的G + C含量可在150 - 200 bp的周期内波动，这可能是核小体定位的一个因素。本文讨论了诱变在CpG缺失和A + T增加中的作用，特别是在非编码区域。
