Department of Oncology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Dis Markers. 2022 Jun 1;2022:1844352. doi: 10.1155/2022/1844352. eCollection 2022.
Hepatocellular carcinoma (HCC) is highly aggressive with a poor prognosis and survival rate. Certain ANGPTL members have been implicated in tumor progression. However, the relevance of the ANGPTL gene family to HCC remains poorly understood. In this study, we explored the role of ANGPTLs in the prognosis of HCC.
From the CCLE database, we studied the expression of ANGPTLs in a range of cancer cell lines. The UCSC, HCCDB, and Human Protein Atlas databases were used to analyze the differences in mRNA and protein expression of ANGPTLs in HCC tissues. Additionally, the correlation between ANGPTL mRNA and methylation levels and clinicopathological features were assessed in the TCGA database. The correlation between ANGPTL mRNA and overall survival was determined by the Kaplan-Meier plotter. cBioPortal database was used to analyze ANGPTL genomic alterations. Genes associated with ANGPTLs were determined by enrichment with KEGG. Moreover, the differentially expressed genes of ANGPTLs were analyzed by the LinkedOmics database, and the KEGG pathway and miRNA targets of ANGPTLs were also enriched.
There was a significant correlation between the ANGPTL members (excluding ANGPTL2) and the prognosis of HCC patients according to the Kaplan-Meier plotter analysis ( < 0.05). ANGPTL1 was the gene with the highest mutation frequency. ANGPTLs are involved in certain pathways that may influence the development of HCC.
In summary, the expression of some members of ANGPTLs was significantly correlated with HCC prognosis, suggesting that the ANGPTL gene family members may be promising molecular markers for HCC treatment and prognosis.
肝细胞癌 (HCC) 侵袭性强，预后和生存率差。某些 ANGPTL 成员与肿瘤进展有关。然而，ANGPTL 基因家族与 HCC 的相关性仍知之甚少。在这项研究中，我们探讨了 ANGPTLs 在 HCC 预后中的作用。
从 CCLE 数据库中，我们研究了一系列癌细胞系中 ANGPTLs 的表达。使用 UCSC、HCCDB 和 Human Protein Atlas 数据库分析 HCC 组织中 ANGPTLs 的 mRNA 和蛋白表达差异。此外，在 TCGA 数据库中评估了 ANGPTL mRNA 和甲基化水平与临床病理特征的相关性。通过 Kaplan-Meier 绘图器确定 ANGPTL mRNA 与总生存期的相关性。使用 cBioPortal 数据库分析 ANGPTL 基因组改变。通过 KEGG 富集确定与 ANGPTLs 相关的基因。此外，通过 LinkedOmics 数据库分析 ANGPTLs 的差异表达基因，并对 ANGPTLs 的 KEGG 通路和 miRNA 靶标进行富集。
根据 Kaplan-Meier 绘图器分析，ANGPTL 成员（不包括 ANGPTL2）与 HCC 患者的预后有显著相关性（<0.05）。ANGPTL1 是突变频率最高的基因。ANGPTLs 参与了某些可能影响 HCC 发展的途径。
总之，一些 ANGPTLs 成员的表达与 HCC 预后显著相关，表明 ANGPTL 基因家族成员可能是 HCC 治疗和预后的有前途的分子标志物。
