Su Xin, Xu Qinchen, Li Zigan, Ren Yidan, Jiao Qinlian, Wang Lina, Wang Yunshan
Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.
Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong Province, China.
Heliyon. 2024 Mar 12;10(7):e27739. doi: 10.1016/j.heliyon.2024.e27739. eCollection 2024 Apr 15.
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease, with a range of conditions including non-alcoholic fatty liver, non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Currently recognized as the liver component of the metabolic syndrome, NAFLD is intimately linked to metabolic diseases. Angiopoietin-like proteins (ANGPTLs) comprise a class of proteins that resemble angiopoietins structurally. It is closely related to obesity, insulin resistance and lipid metabolism, and may be the critical factor of metabolic syndrome. In recent years, many studies have found that there is a certain correlation between ANGPTLs and the occurrence and progression of NAFLD disease spectrum. This article reviews the possible mechanisms and roles of ANGPTL protein in the pathogenesis and progression of NAFLD.
非酒精性脂肪性肝病（NAFLD）是慢性肝病最常见的病因，包括一系列病症，如非酒精性脂肪肝、非酒精性脂肪性肝炎、肝硬化和肝细胞癌（HCC）。NAFLD目前被认为是代谢综合征的肝脏组成部分，与代谢性疾病密切相关。血管生成素样蛋白（ANGPTLs）是一类在结构上类似于血管生成素的蛋白质。它与肥胖、胰岛素抵抗和脂质代谢密切相关，可能是代谢综合征的关键因素。近年来，许多研究发现ANGPTLs与NAFLD疾病谱的发生和进展之间存在一定的相关性。本文综述了ANGPTL蛋白在NAFLD发病机制和进展中的可能机制及作用。
