Department of Orthopaedics, Fuzhou Second Hospital, The Third Clinical Medical College, Fujian Medical University, Fuzhou 350007, China.
Department of Orthopaedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Fuzhou 350007, China.
Dis Markers. 2022 Jun 2;2022:6119583. doi: 10.1155/2022/6119583. eCollection 2022.
The diagnostic value of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in predicting fracture-related infection (FRI) in tibia fracture patients remains to be explored.
A retrospective controlled study was carried out with 170 tibia FRI patients and 162 control subjects. The following information was evaluated at admission: age, gender, clinical features, number of white blood cells (WBCs), neutrophils, lymphocytes, monocytes, red blood cells (RBCs), platelets, level of hemoglobin, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), as well as NLR, MLR, and PLR.
The number of lymphocytes, RBCs, and platelets in the FRI group was higher than those in the control group, while the number of neutrophils and ESR level was lower ( < 0.05). The level of NLR and MLR was significantly lower in patients with tibia FRI than in control subjects ( < 0.05). Both indicators were positively correlated with WBCs, CRP level, and ESR level ( < 0.001). The results of logistic regression analysis showed that five variables including NLR, MLR, platelets, fracture pattern (closed or open fracture), and site pattern (single or multiple site) were used to construct the FRI risk predictor. The ROC curve analysis result showed that FRI risk predictor yielded the highest AUC, with a sensitivity of 91.2% and a specificity of 90.1%, and made the distinction efficiently between tibia FRI patients and non-FRI patients.
NLR and MLR were decreased in tibia FRI patients compared to non-FRI patients. Both indicators had a positive correlation with WBCs, CRP level, and ESR level. FRI risk predictor constructed based on five variables including NLR and MLR had a high diagnostic value for tibia FRI.
中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）和血小板与淋巴细胞比值（PLR）在预测胫骨骨折患者骨折相关感染（FRI）中的诊断价值仍有待探讨。
对 170 例胫骨 FRI 患者和 162 例对照者进行回顾性对照研究。入院时评估以下信息：年龄、性别、临床特征、白细胞（WBC）计数、中性粒细胞、淋巴细胞、单核细胞、红细胞（RBC）计数、血小板计数、血红蛋白水平、C 反应蛋白（CRP）和红细胞沉降率（ESR），以及 NLR、MLR 和 PLR。
FRI 组淋巴细胞、RBC 计数和血小板计数高于对照组，而中性粒细胞计数和 ESR 水平较低（<0.05）。与对照组相比，胫骨 FRI 患者的 NLR 和 MLR 水平显著降低（<0.05）。两个指标均与 WBC 计数、CRP 水平和 ESR 水平呈正相关（<0.001）。Logistic 回归分析结果显示，NLR、MLR、血小板计数、骨折类型（闭合或开放骨折）和部位模式（单一或多个部位）等 5 个变量用于构建 FRI 风险预测因子。ROC 曲线分析结果显示，FRI 风险预测因子的 AUC 最高，灵敏度为 91.2%，特异性为 90.1%，能有效区分胫骨 FRI 患者和非 FRI 患者。
与非 FRI 患者相比，胫骨 FRI 患者的 NLR 和 MLR 降低。两个指标均与 WBC 计数、CRP 水平和 ESR 水平呈正相关。基于 NLR 和 MLR 等 5 个变量构建的 FRI 风险预测因子对胫骨 FRI 具有较高的诊断价值。
