中性粒细胞与淋巴细胞比值、单核细胞与淋巴细胞比值、血小板与淋巴细胞比值、C 反应蛋白和癌抗原 125 对卵巢癌的诊断作用。
Diagnostic roles of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein, and cancer antigen 125 for ovarian cancer.
机构信息
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
School of Medicine, Taizhou University, Taizhou, Zhejiang, China.
出版信息
J Int Med Res. 2023 Dec;51(12):3000605231218557. doi: 10.1177/03000605231218557.
OBJECTIVE
To compare the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP) level, and cancer antigen 125 (CA125) level for ovarian cancer (OC).
METHODS
Data of 72 patients with OC, 50 patients with benign ovarian disease, and 46 healthy controls were retrospectively analyzed, and receiver operating characteristic analysis was performed.
RESULTS
The platelet count was higher in patients with a tumor diameter of ≥10 vs. <10 cm. The absolute lymphocyte count was significantly higher in patients with stage I/II OC than in those with multiple and stage III/IV OC. The absolute monocyte count, NLR, MLR, and CA125 were significantly higher in patients with multiple and stage III/IV OC than in those with single and stage I/II OC. The NLR, PLR, MLR, fibrinogen, D-dimer, CRP, and CA125 were useful for distinguishing between the OC and healthy control groups.
CONCLUSIONS
Our analysis showed that the following combinations have practical diagnostic value in OC: NLR + PLR + MLR + CA125, NLR + PLR + MLR + CA125 + CRP, NLR + MLR +PLR + CA125 + CRP + fibrinogen, and NLR + MLR + PLR + CA125 + CRP + fibrinogen + D-dimer.
目的
比较中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、C 反应蛋白（CRP）水平和癌抗原 125（CA125）水平对卵巢癌（OC）的诊断价值。
方法
回顾性分析了 72 例 OC 患者、50 例良性卵巢疾病患者和 46 名健康对照者的数据，并进行了受试者工作特征分析。
结果
肿瘤直径≥10cm 者的血小板计数较高。I/II 期 OC 患者的绝对淋巴细胞计数明显高于多灶和 III/IV 期 OC 患者。多灶和 III/IV 期 OC 患者的绝对单核细胞计数、NLR、MLR 和 CA125 明显高于单灶和 I/II 期 OC 患者。NLR、PLR、MLR、纤维蛋白原、D-二聚体、CRP 和 CA125 有助于区分 OC 患者和健康对照组。
结论
我们的分析表明，以下组合在 OC 中有实用的诊断价值：NLR+PLR+MLR+CA125、NLR+PLR+MLR+CA125+CRP、NLR+MLR+PLR+CA125+CRP+纤维蛋白原和 NLR+MLR+PLR+CA125+CRP+纤维蛋白原+D-二聚体。
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