Yang Qinghua, Sun Chengcheng, Zhao Lisha
Department of Anorectal Surgery, Yiwu Central Hospital of Zhejiang Province, Yiwu, China.
Department of Anesthesiology, Yiwu Central Hospital of Zhejiang Province, Yiwu, China.
Front Surg. 2022 May 25;9:906074. doi: 10.3389/fsurg.2022.906074. eCollection 2022.
Colorectal cancer (CRC) is one of the major causes of death in the world, and has become a serious threat to human life. The prognosis of CRC patients in different pathological stages is quite different, so it is necessary to evaluate the clinical stages of CRC patients before surgery. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), serum amyloid A (SAA) and other indicators have been widely proved to play the role of early diagnosis and prognosis monitoring in chronic inflammatory diseases and cancers. In this study, we collected clinical data of 103 patients with CRC confirmed by pathology in Yiwu Central Hospital from January 2019 to December 2021. In addition, it aims to explore the expression and predictive value of NLR, PLR combined with SAA in patients with different stages of CRC, so as to provide reference for patients to choose a reasonable treatment plan. The results show that serum NLR, PLR combined with SAA can predict CRC staging effectively, which has certain auxiliary value for clinical decision-making.
结直肠癌（CRC）是全球主要死因之一，已成为对人类生命的严重威胁。不同病理阶段的CRC患者预后差异很大，因此在手术前评估CRC患者的临床分期很有必要。中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、血清淀粉样蛋白A（SAA）等指标已被广泛证明在慢性炎症性疾病和癌症中具有早期诊断和预后监测作用。本研究收集了2019年1月至2021年12月在义乌市中心医院经病理确诊的103例CRC患者的临床资料。此外，旨在探讨NLR、PLR联合SAA在不同分期CRC患者中的表达及预测价值，为患者选择合理的治疗方案提供参考。结果表明，血清NLR、PLR联合SAA能有效预测CRC分期，对临床决策具有一定的辅助价值。
