接受非小细胞肺癌手术患者特定血小板参数的预后价值

Prognostic value of selected platelet parameters of patients operated for non-small cell lung cancer.

作者信息

Łochowski Mariusz, Rębowski Marek, Chałubińska-Fendler Justyna, Zawadzka Izabela, Łochowska Barbara, Cieślik-Wolski Bartosz, Kozak Józef

机构信息

Clinic of Thoracic Surgery and Respiratory Rehabilitation, Medical University of Lodz, Regional Multi-Specialist Center for Oncology and Traumatology of the Nicolaus Copernicus Memorial Hospital in Lodz, Lodz, Poland.

Department of Radiotherapy, Military Institute of Medicine, Warsaw, Poland.

出版信息

J Thorac Dis. 2022 May;14(5):1374-1383. doi: 10.21037/jtd-21-1401.

DOI:10.21037/jtd-21-1401

PMID:35693601

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9186231/

Abstract

BACKGROUND

Platelets play a vital role in the neoplastic process. Platelet parameters are hence an important source of information concerning ongoing neoplastic disease. The aim of the study is to assess the impact of selected platelet parameters on the survival of patients with non-small cell lung cancer (NSCLC).

METHODS

The study included 532 (174 female and 358 male) patients aged 36-84 years (mean age 63.6 years) operated on due to NSCLC, staged IA-IIIA. Before the operation, all patients received a blood morphology test. The following parameters were subjected to statistical analysis: platelet count, mean platelet volume (MPV) parameter, platelet distribution width (PDW) parameter, platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation (SII) index. These findings were compared with the clinical data of the patients, and the probability of overall survival was analyzed.

RESULTS

The univariate analysis revealed a correspondence between PDW, MPV, PLR and SII index and patient survival. The multivariate analysis including patient clinical data found the following factors to have negative prognostic value for patients operated on due to NSCLC: male sex, advancement stage of neoplastic disease and Charlson Comorbidity Index (CCI) above 4, and PLR >144.

CONCLUSIONS

PDW value, PLR and SII index are independent prognostic factors. In the multi-factor model, male sex, the advancement stage of the neoplastic disease, CCI above 4 and PLR lower than 144 had the greatest prognostic value.

摘要

背景

血小板在肿瘤形成过程中发挥着至关重要的作用。因此，血小板参数是有关正在发生的肿瘤疾病的重要信息来源。本研究的目的是评估选定的血小板参数对非小细胞肺癌（NSCLC）患者生存的影响。

方法

本研究纳入了532例（174例女性和358例男性）年龄在36 - 84岁（平均年龄63.6岁）因NSCLC接受手术的患者，分期为IA - IIIA期。术前，所有患者均接受了血液形态学检查。对以下参数进行了统计分析：血小板计数、平均血小板体积（MPV）参数、血小板分布宽度（PDW）参数、血小板与淋巴细胞比值（PLR）和全身免疫炎症（SII）指数。将这些结果与患者的临床数据进行比较，并分析总生存概率。