Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Department of Endocrinology, Ansteel Group Hospital, AnShan, Liaoning, 114001, China.
Sci Rep. 2017 Jun 14;7(1):3456. doi: 10.1038/s41598-017-03772-z.
Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients' characteristics and hematologic tests data at initial diagnosis were collected. The overall survival rate was estimated using Kaplan-Meier method. The prognostic analysis was carried out with univariate and multivariate Cox regressions model. Reduced PDW was significantly correlated with T stage, N stage, TNM stage, and histological type of the disease. Moreover, survival analysis showed that the overall survival of patients with PDW ≥ 16.3% was significantly longer than that of those with PDW < 16.3% (P < 0.001). In multivariate Cox regression model, age, sex, TNM stage, and PDW were identified as independent prognostic factors for overall survival (for PDW, P < 0.001). In conclusion, reduced PDW is an unfavorable predictive factor of NSCLC patient survival. Further studies are warranted.
血小板在癌症的进展和转移中发挥着多方面的作用。平均血小板体积（MPV）和血小板分布宽度（PDW）是常规血液检查中常用的血小板参数。本研究旨在探讨血小板指数与非小细胞肺癌（NSCLC）患者预后的相关性。回顾性分析了 2009 年 1 月至 2009 年 12 月期间诊断为 NSCLC 的 270 例患者。收集了患者的特征和初诊时的血液学检查数据。使用 Kaplan-Meier 法估计总生存率。采用单因素和多因素 Cox 回归模型进行预后分析。较低的 PDW 与 T 分期、N 分期、TNM 分期和疾病的组织学类型显著相关。此外，生存分析表明，PDW≥16.3%的患者的总生存率明显长于 PDW<16.3%的患者（P<0.001）。在多因素 Cox 回归模型中，年龄、性别、TNM 分期和 PDW 被确定为总生存率的独立预后因素（对于 PDW，P<0.001）。总之，较低的 PDW 是非小细胞肺癌患者生存的不利预测因素。需要进一步研究。
