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[3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors.

作者信息

Wessler I, Scheuer B, Kilbinger H

出版信息

Eur J Pharmacol. 1987 Mar 3;135(1):85-7. doi: 10.1016/0014-2999(87)90760-6.

DOI:10.1016/0014-2999(87)90760-6
PMID:3569426
Abstract

Nicotinic agonists (nicotine, 1,1-dimethyl-4-phenylpiperazinium (DMPP) increased [3H]acetylcholine release when the pre-exposure time was short (20 s). This effect was antagonized by pretreatment with d-tubocurarine (d-TC), which indicates a receptor-mediated effect. After a longer pre-exposure time (3 min) 10 microM nicotine significantly decreased the evoked [3H]acetylcholine release, probably because desensitization of the nicotine autoreceptors had abolished the nicotinic autofacilitation of transmitter release.

摘要

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