β-肾上腺素能受体刺激可增强大鼠膈神经的递质释放。
Beta-adrenoceptor stimulation enhances transmitter output from the rat phrenic nerve.
作者信息
Wessler I, Anschütz S
机构信息
Department of Pharmacology, University of Mainz, F.R.G.
出版信息
Br J Pharmacol. 1988 Jul;94(3):669-74. doi: 10.1111/j.1476-5381.1988.tb11574.x.
Abstract
- Neurally-evoked output of newly synthesized [3H]-acetylcholine from the rat phrenic nerve was measured in the absence of cholinesterase inhibitors. 2. Noradrenaline and isoprenaline enhanced neurally-evoked transmitter output markedly. Moreover, immediately after the application of noradrenaline the basal tritium efflux increased significantly. 3. Pretreatment with propranolol (0.1 mumol l-1) or atenolol (0.3 mumol l-1) completely prevented the stimulatory effect of noradrenaline and isoprenaline on evoked transmitter output. 4. The facilitatory effect of isoprenaline declined, when the exposure time was increased. This observation supports the assumption that beta-adrenoceptors can be desensitized or inactivated during continued exposure to agonists. 5. It was shown for the first time that stimulation of beta-adrenoceptors enhances transmitter output from the motor nerve. It is proposed that these beta-adrenoceptors are of the beta 1-subtype and are localized on the endings of motor nerves. Circulating catecholamines may facilitate neuromuscular transmission by stimulation of presynaptic beta-adrenoceptors.
摘要
- 在不存在胆碱酯酶抑制剂的情况下，测量了大鼠膈神经新合成的[3H] - 乙酰胆碱的神经诱发输出。2. 去甲肾上腺素和异丙肾上腺素显著增强神经诱发的递质输出。此外，施加去甲肾上腺素后立即，基础氚外流显著增加。3. 用普萘洛尔（0.1 μmol l-1）或阿替洛尔（0.3 μmol l-1）预处理可完全阻止去甲肾上腺素和异丙肾上腺素对诱发递质输出的刺激作用。4. 当暴露时间增加时，异丙肾上腺素的促进作用下降。这一观察结果支持了在持续暴露于激动剂期间β - 肾上腺素能受体可被脱敏或失活的假设。5. 首次表明刺激β - 肾上腺素能受体可增强运动神经的递质输出。有人提出这些β - 肾上腺素能受体属于β1亚型，位于运动神经末梢。循环中的儿茶酚胺可能通过刺激突触前β - 肾上腺素能受体促进神经肌肉传递。
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本文引用的文献
1
Some statistical methods useful in circulation research.一些在循环研究中有用的统计方法。
Circ Res. 1980 Jul;47(1):1-9. doi: 10.1161/01.res.47.1.1.
2
Presynaptic receptors.突触前受体
Annu Rev Pharmacol Toxicol. 1981;21:7-30. doi: 10.1146/annurev.pa.21.040181.000255.
3
Effects of catecholamines on the neuromuscular junction in the rat diaphragm.儿茶酚胺对大鼠膈肌神经肌肉接头的影响。
J Physiol. 1970 Dec;211(3):551-70. doi: 10.1113/jphysiol.1970.sp009293.
4
The effect of adrenaline on the contraction of human muscle.肾上腺素对人体肌肉收缩的影响。
J Physiol. 1970 Apr;207(2):429-48. doi: 10.1113/jphysiol.1970.sp009071.
5
Effects of sympathomimetic amines on neuromuscular transmission.拟交感胺对神经肌肉传递的影响。
Br J Pharmacol Chemother. 1966 Aug;27(2):313-31. doi: 10.1111/j.1476-5381.1966.tb01665.x.
6
The effects of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline and aminophylline on neuromuscular transmission in the rat.二丁酰环磷腺苷、茶碱和氨茶碱对大鼠神经肌肉传递的影响。
J Pharmacol Exp Ther. 1974 Feb;188(2):447-52.
7
Muscarine receptors on the rat phrenic nerve, evidence for positive and negative muscarinic feedback mechanisms.大鼠膈神经上的毒蕈碱受体，毒蕈碱正负反馈机制的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jun;335(6):605-12. doi: 10.1007/BF00166975.
8
Uptake and metabolism of [3H]choline by the rat phrenic nerve-hemidiaphragm preparation.大鼠膈神经-半横膈标本对[3H]胆碱的摄取与代谢
Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):231-7. doi: 10.1007/BF00172789.
9
[3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors.
Eur J Pharmacol. 1987 Mar 3;135(1):85-7. doi: 10.1016/0014-2999(87)90760-6.
10
Beta-adrenergic receptors and their mode of coupling to adenylate cyclase.β-肾上腺素能受体及其与腺苷酸环化酶的偶联方式。
Physiol Rev. 1986 Jul;66(3):819-54. doi: 10.1152/physrev.1986.66.3.819.
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