Van Remoortel Samuel, Lambeets Lana, Timmermans Jean-Pierre
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Anat Rec (Hoboken). 2023 May;306(5):1131-1139. doi: 10.1002/ar.25008. Epub 2022 Jun 13.
Over the past decade, the research field dealing with the role of a new family of Rhodopsin A-like G protein-coupled receptors, that is, the family of Mas-related G protein-coupled receptors (Mrgprs) has expanded enormously. A plethora of recent studies have provided evidence that Mrgprs are key players in itch and pain, as well as in the initiation and modulation of inflammatory/allergic responses in the skin. Over the years, it has become clear that this role is not limited to the skin, but extends to other mucosal surfaces such as the respiratory tract and the gastrointestinal (GI) tract. In the GI tract, Mrgprs have emerged as novel interoceptive sensory pathways linked to health and disease, and are in close functional association with the gut's immune system. This review aims to provide an update of our current knowledge on the expression, distribution and function of members of this Mrgpr family in intrinsic and extrinsic neuro-immune pathways related to the GI system.
在过去十年中，研究领域中涉及一类新的视紫红质A样G蛋白偶联受体，即Mas相关G蛋白偶联受体（Mrgprs）家族的作用的研究有了极大的扩展。最近大量的研究表明，Mrgprs在瘙痒和疼痛以及皮肤炎症/过敏反应的起始和调节中起着关键作用。多年来，很明显这种作用不仅限于皮肤，还扩展到其他黏膜表面，如呼吸道和胃肠道（GI）。在胃肠道中，Mrgprs已成为与健康和疾病相关的新型内感受性感觉通路，并与肠道免疫系统密切相关。本综述旨在更新我们目前对该Mrgpr家族成员在与胃肠道系统相关的内在和外在神经免疫途径中的表达、分布和功能的认识。
