Alzheimer's Disease and Related Disorders Center, Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Department of Neurology, Shanghai General Hospital, Shanghai, P.R. China.
J Alzheimers Dis. 2022;88(2):641-651. doi: 10.3233/JAD-220279.
Bone morphogenetic protein (BMP) plays important roles in the pathology of Alzheimer's disease (AD).
We sought blood BMP6 involved in the processes underlying cognitive decline and detected them in association with AD.
A total of 309 participants in Shanghai Mental Health Center (SMHC) and 547 participants in Alzheimer's disease Neuroimaging Initiative (ADNI) cohort were included. Blood BMP6 and cognitive functions were measured in all subjects of both cohorts at baseline, and in 482 subjects of ADNI cohort after one year. A total of 300 subjects in ADNI cohort were detected cerebrospinal fluid (CSF) tau biomarker, and 244 received 1-year follow-up.
AD patients had lower levels of blood BMP6 compared to normal controls, and BMP6 was positively associated with cognitive functions. Longitudinal BMP6 combing with APOE genotype could distinguish probable AD from normal controls. The influence of blood BMP6 on cognition was modulated by tau pathology.
Blood BMP6 was associated with cognitive performance and identified as a potential predictor for probable AD.
骨形态发生蛋白（BMP）在阿尔茨海默病（AD）的发病机制中发挥重要作用。
我们试图寻找与认知能力下降相关的血液 BMP6，并检测其与 AD 的关联。
共纳入上海精神卫生中心（SMHC）的 309 名参与者和阿尔茨海默病神经影像学倡议（ADNI）队列的 547 名参与者。所有参与者在基线时均测量了血液 BMP6 和认知功能，ADNI 队列中的 482 名参与者在一年后进行了测量。ADNI 队列中的 300 名参与者检测了脑脊液（CSF）tau 生物标志物，其中 244 名接受了为期 1 年的随访。
与正常对照组相比，AD 患者的血液 BMP6 水平较低，BMP6 与认知功能呈正相关。纵向 BMP6 结合 APOE 基因型可将可能的 AD 与正常对照组区分开来。血液 BMP6 对认知的影响受 tau 病理学的调节。
血液 BMP6 与认知表现相关，可作为可能的 AD 的潜在预测指标。
