Sun Lin, Qiu Qi, Ban Chunxia, Fan Sijia, Xiao Shifu, Li Xia
Department of Geriatric Psychiatry, Alzheimer's Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wanping Road, Xuhui Distinct, Shanghai, People's Republic of China.
Department of Psychiatry, Jiading Mental Health Center, Shanghai, People's Republic of China.
Cogn Neurodyn. 2023 Jun;17(3):695-701. doi: 10.1007/s11571-022-09855-6. Epub 2022 Aug 3.
Bone morphogenetic protein 6 (BMP6) and noggin both have been implicated in the pathophysiology of chronic dementia, and chronic schizophrenia (SCZ) has high risk for progressing to dementia in later life. The current study investigated the relationship between blood BMP6/noggin levels and cognitive function in chronic SCZ elderly.
A total of 159 chronic SCZ elderly and 171 community normal controls (NC) were involved in the present study. Blood cytokines including BMP6 and its antagonist-noggin, and cognitive function were measured in all subjects, 157 subjects among them received apolipoprotein E () genotype test, and 208 subjects received cognitive assessment at 1-year follow-up.
Chronic SCZ elderly had decreased levels of blood BMP6 and noggin compared to healthy controls, especially in the subgroup of chronic SCZ with dementia. Blood BMP6 combing with noggin could distinguish chronic SCZ from NC elderly. ε4 carriers had lower levels of BMP6 than non-ε4 carriers under chronic SCZ.
There was a significant relationship of blood BMP6/noggin with cognitive performance in chronic SCZ.
骨形态发生蛋白6（BMP6）和头蛋白均与慢性痴呆的病理生理学有关，而慢性精神分裂症（SCZ）在晚年发展为痴呆的风险较高。本研究调查了慢性SCZ老年患者血液中BMP6/头蛋白水平与认知功能之间的关系。
本研究共纳入159例慢性SCZ老年患者和171例社区正常对照（NC）。测量了所有受试者的血液细胞因子，包括BMP6及其拮抗剂头蛋白，以及认知功能，其中157例受试者接受了载脂蛋白E（）基因分型检测，208例受试者在1年随访时接受了认知评估。
与健康对照相比，慢性SCZ老年患者血液中BMP6和头蛋白水平降低，尤其是在伴有痴呆的慢性SCZ亚组中。血液中的BMP6与头蛋白相结合可以区分慢性SCZ老年患者和NC老年患者。在慢性SCZ患者中，ε4携带者的BMP6水平低于非ε4携带者。
慢性SCZ患者血液中的BMP6/头蛋白与认知表现之间存在显著关系。
