无蛋白饮食对大鼠肝脏支链酮酸脱氢酶复合体和激酶活性影响的时间关系
Temporal relationships in the effects of protein-free diet on the activities of rat liver branched-chain ketoacid dehydrogenase complex and kinase.
作者信息
Beggs M, Patel H, Espinal J, Randle P J
出版信息
FEBS Lett. 1987 May 4;215(1):13-5. doi: 10.1016/0014-5793(87)80104-7.
PMID:3569535
Abstract
Feeding rats 0% casein diet decreased liver activities of branched-chain ketoacid dehydrogenase complex (active form) and of activator protein (complete within 4 days), and increased activity of branched-chain ketoacid dehydrogenase kinase (complete within 9-10 days). Refeeding normal diet to rats fed 0% casein diet for 10 days resulted in a rapid and partial (approx. 50%) reversal of the above effects within 24 h; complete reversal required 20-30 days of refeeding.
摘要
给大鼠喂食0%酪蛋白饮食会降低支链酮酸脱氢酶复合体（活性形式）和激活蛋白的肝脏活性（4天内完成），并增加支链酮酸脱氢酶激酶的活性（9 - 10天内完成）。给喂食0%酪蛋白饮食10天的大鼠重新喂食正常饮食，上述影响在24小时内迅速且部分（约50%）逆转；完全逆转需要重新喂食20 - 30天。
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