Matson P L, Yovich J M, Bootsma B D, Spittle J W, Yovich J L
Fertil Steril. 1987 May;47(5):802-6. doi: 10.1016/s0015-0282(16)59168-7.
Gamete intrafallopian transfer (GIFT) was performed on a series of 42 couples in whom four oocytes were replaced into the fallopian tubes and the remaining oocytes were inseminated with 100,000 motile spermatozoa. Fertilization in vitro was assessed 16 to 20 hours later. An overall pregnancy rate after GIFT of 40.0% (12/30) in normospermic couples and 16.7% (2/12) in oligospermic couples was seen. Supernumerary oocytes were submitted to in vitro fertilization (IVF) and the findings related to the likelihood of pregnancy. No correlation between IVF and the likelihood of GIFT pregnancies was found in either the oligospermic or normospermic couples. A similar proportion of pregnancies was seen in couples with or without evidence of fertilization of the supernumerary oocytes in both the oligospermic and normospermic couples. However, a high proportion of normospermic couples with no evidence of fertilization had only one oocyte remaining for insemination. These results suggest that the failure of low numbers of supernumerary oocytes to fertilize in vitro after GIFT relates to oocyte selection criteria and does not mean a reduced chance of conception in that treatment cycle.
对42对夫妇进行了配子输卵管内移植（GIFT），将4个卵母细胞移植到输卵管中，其余卵母细胞与100,000个活动精子进行授精。16至20小时后评估体外受精情况。在正常精子数的夫妇中，GIFT后的总体妊娠率为40.0%（12/30），在少精子症夫妇中为16.7%（2/12）。多余的卵母细胞进行体外受精（IVF），并观察与妊娠可能性相关的结果。在少精子症或正常精子数的夫妇中，均未发现IVF与GIFT妊娠可能性之间存在相关性。在少精子症和正常精子数的夫妇中，有或没有多余卵母细胞受精证据的夫妇中，妊娠比例相似。然而，很大一部分没有受精证据的正常精子数夫妇只剩下一个卵母细胞用于授精。这些结果表明，GIFT后少量多余卵母细胞体外受精失败与卵母细胞选择标准有关，并不意味着该治疗周期受孕机会降低。
