Department of Pharmaceutical Services and Sciences, Children's Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt.
Department of Clinical Research, Children's Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt.
J Egypt Natl Canc Inst. 2022 Jun 13;34(1):25. doi: 10.1186/s43046-022-00126-3.
The therapy design of childhood acute lymphoblastic leukemia (ALL) has evolved over the past 60 years. The St. Jude Children's Research Hospital has developed 17 treatment protocols from 1962 to 2017, aiming to have the most effective and least toxic treatment form. This review summarizes each protocol's objectives, inclusion criteria, treatment phases, pharmacological agents, irradiation therapy, response criteria, risk stratification, type of relapse, and overall survival. The enhancement and successful application of preventive therapy for ALL and following a risk-stratified approach have progressively improved the cure rate of childhood ALL, with relatively few adverse sequelae. Moreover, St. Jude's scientific theme serves as a reminder of the principal factor of research directed to a catastrophic disease such as ALL.
儿童急性淋巴细胞白血病（ALL）的治疗设计在过去 60 年中不断发展。圣裘德儿童研究医院从 1962 年到 2017 年制定了 17 种治疗方案，旨在采用最有效和毒性最小的治疗形式。这篇综述总结了每个方案的目标、纳入标准、治疗阶段、药物制剂、放疗、反应标准、风险分层、复发类型和总生存率。ALL 的预防治疗的加强和成功应用，以及风险分层方法的应用，逐渐提高了儿童 ALL 的治愈率，且不良后果相对较少。此外，圣裘德的科学主题提醒人们，对于 ALL 等灾难性疾病的研究，主要因素是针对疾病本身。
