Physiotherapy Research Unit, Faculty of Medicine, Universidad Nacional Autónoma de México, Dr. Márquez 162 Colonia Doctores , Mexico City, 06720, Mexico.
Research Department, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
BMC Pediatr. 2023 Oct 16;23(1):513. doi: 10.1186/s12887-023-04316-3.
We evaluated fine motor skills; precision, motor integration, manual dexterity, and upper-limb coordination according to sex and risk stratification in children with Acute Lymphoblastic Leukaemia (ALL).
We evaluated twenty-nine children in the maintenance phase aged 6 to 12 years with the Bruininks-Oseretsky Test of Motor Proficiency-second edition (BOT-2), and sex and age-specific norm values of BOT-2 were used to compare our results.
We found lower scores on the upper-limb coordination subtest, p = 0.003 and on the manual coordination composite, p = 0.008, than normative values. Most boys performed "average" on both the subtests and the composites, but girls showed lower scores with a mean difference of 7.69 (95%CI; 2.24 to 3.14), p = 0.009. Girls' scale scores on the upper-limb coordination subtest were lower than normative values, with mean difference 5.08 (95%CI; 2.35 to 7.81), p = 0.006. The mean standard score difference in high-risk patients was lower than normative on the manual coordination composite, 8.18 (95%CI; 2.26 to 14.1), p = 0.015. High-risk children also performed below the BOT-2 normative on manual dexterity 2.82 (95%CI; 0.14 to 5.78), p = 0.035 and upper limb coordination subtest 4.10 (95%CI; 1.13 to 7.05), p = 0.028. We found a decrease in fine motor precision in children with a higher BMI, rho= -0.87, p = 0.056 and a negative correlation between older age and lower manual dexterity, r= -0.41 p = 0.026; however, we did not find any correlation with the weeks in the maintenance phase.
Fine motor impairments are common in children with ALL in the maintenance phase; it is important to identify these impairments to early rehabilitation.
我们评估了精细运动技能；根据性别和危险分层，评估了急性淋巴细胞白血病（ALL）患儿的准确性、运动整合、手灵巧度和上肢协调性。
我们评估了 29 名处于维持期的 6 至 12 岁儿童的布鲁因克斯-奥塞尔斯基运动能力测试第二版（BOT-2），并使用 BOT-2 的性别和年龄特定标准值来比较我们的结果。
我们发现，在上肢协调测验（p=0.003）和手的协调综合测验（p=0.008）上的得分低于正常值。大多数男孩在这两个测验和综合测验中表现为“平均”水平，但女孩的得分较低，平均差异为 7.69（95%CI；2.24 至 3.14），p=0.009。女孩在上肢协调测验的量表评分低于正常值，平均差异为 5.08（95%CI；2.35 至 7.81），p=0.006。高危患者的平均标准分数差异低于正常值，在手部协调综合测验中为 8.18（95%CI；2.26 至 14.1），p=0.015。高危儿童在手部灵巧度 2.82（95%CI；0.14 至 5.78）和上肢协调测验 4.10（95%CI；1.13 至 7.05）上的表现也低于 BOT-2 正常值，p=0.035 和 0.028。我们发现，BMI 较高的儿童的精细运动精度下降，rho=-0.87，p=0.056，年龄较大与手部灵巧度较低之间存在负相关，r=-0.41，p=0.026；然而，我们没有发现与维持阶段的周数有任何相关性。
在维持阶段的 ALL 患儿中，精细运动障碍很常见；重要的是要早期识别这些障碍并进行康复。
