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6,7-二甲氧基-2,2-二甲基-2H-色烯（紫铆因）通过靶向炎症皮肤中的Janus激酶对丝聚合蛋白表达恢复的影响

Effect of 6,7-dimethoxy-2,2-dimethyl-2H-chromene (agerarin) on the recovery of filaggrin expression through targeting of Janus kinases in the inflammatory skin.

作者信息

Ahn Sung Shin, Lee Young Han, Yeo Hyunjin, Lee Youngshim, Min Do Sik, Lim Yoongho, Shin Soon Young

机构信息

Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea.

Cancer and Metabolism Institute, Konkuk University, Seoul, Republic of Korea.

出版信息

J Food Drug Anal. 2020 Sep 15;28(3):449-460. doi: 10.38212/2224-6614.1178.

DOI:10.38212/2224-6614.1178
PMID:35696096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9261804/
Abstract

Filaggrin (FLG) is a structural component of the stratum corneum that is essential for maintaining the barrier function of the skin and for the formation of natural moisturizing factors. 6,7-Dimethoxy-2,2-dimethyl-2H-chromene (Agerarin) is a bioactive compound derived from Ageratum houstonianum, a plant that is used as a traditional medicine to treat skin diseases. This study aimed to evaluate the effect of agerarin on skin inflammation in a dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. We found that the topical administration of agerarin ameliorates atopic dermatitis-like skin lesions. We also showed that agerarin restores the reduced filaggrin (FLG) expression in DNCB-applied skin sections. Moreover, agerarin decreased phosphorylation of JAK1 and JAK2 kinases to enhance FLG expression, which was reduced by TNFα+IFNγ and IL4+IL13 treatment, in HaCaT keratinocytes. These results demonstrate the feasibility of agerarin as a possible therapeutic against conditions of skin inflammation, such as atopic dermatitis, by improving the upregulation of FLG expression.

摘要

丝聚合蛋白（FLG）是角质层的一种结构成分，对于维持皮肤的屏障功能和天然保湿因子的形成至关重要。6,7-二甲氧基-2,2-二甲基-2H-色烯（藿香色烯）是一种从藿香蓟中提取的生物活性化合物，藿香蓟是一种被用作治疗皮肤病的传统药物的植物。本研究旨在评估藿香色烯对二硝基氯苯（DNCB）诱导的特应性皮炎小鼠模型皮肤炎症的影响。我们发现局部应用藿香色烯可改善特应性皮炎样皮肤损伤。我们还表明，藿香色烯可恢复DNCB处理的皮肤切片中降低的丝聚合蛋白（FLG）表达。此外，在HaCaT角质形成细胞中，藿香色烯降低了JAK1和JAK2激酶的磷酸化以增强FLG表达，而TNFα + IFNγ和IL4 + IL13处理可降低FLG表达。这些结果证明了藿香色烯作为一种可能的治疗皮肤炎症疾病（如特应性皮炎）的可行性，其通过改善FLG表达的上调来实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/237cf9453943/jfda-28-03-449f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/5e6ac1a5e050/jfda-28-03-449f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/cfcadd1ad7c6/jfda-28-03-449f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/9a0177a869d0/jfda-28-03-449f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/237cf9453943/jfda-28-03-449f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/5e6ac1a5e050/jfda-28-03-449f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/7b3ea93d6534/jfda-28-03-449f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/1a3600430040/jfda-28-03-449f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc90/9261804/2693888df0af/jfda-28-03-449f4.jpg
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